Supplement Scholar
Compound

Hydroxytyrosol

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Hydroxytyrosol. Olive polyphenol for cardiovascular health.

How it works. Potent antioxidant; LDL oxidation inhibitor.

What the research supports. 1 graded claims. Strongest: Reduces LDL oxidation (moderate).

How much to take. Typical dose: 15–30 mg.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Omega-3, CoQ10, NAD+ precursor (NMN or NR).

Common forms. Available as Capsule or softgel, Powder, Sublingual or buccal, Liposomal liquid.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Hydroxytyrosol. Anecdotes are not medical advice.

Hydroxytyrosol. Olive polyphenol for cardiovascular health.

Molecular structureC8H10O3 · 154.16 g/mol

What it is

Olive polyphenol for cardiovascular health.

Food sources

Endogenously produced or biosynthesized moleculeStandardized pharmaceutical- or food-grade supplementCombined with cofactors that improve absorption or activity

Goals

Cardiovascular HealthHealthy Aging

How it works

Potent antioxidant; LDL oxidation inhibitor.

Pathways

  • Potent antioxidant
  • LDL oxidation inhibitor

Effects

  • ↓LDL oxidation decreases

What the research supports

Reduces LDL oxidationmoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
15–30 mg
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodWith a meal containing fat for fat-soluble compounds; otherwise either.
Best formMost evidence is based on the capsule or softgel form.
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Side effects & interactions

Common side effects

  • GI upset

Medication interactions

Prescription medications (general)minor

Always disclose Hydroxytyrosol use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Omega-3Anti-inflammatory cardiovascular synergy.
  • CoQ10Supports mitochondrial energetics in cardiac tissue.
  • NAD+ precursor (NMN or NR)Complementary mitochondrial and sirtuin support.

Common forms

  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Key studies

8 studies cited in total.

PubMed: Hydroxytyrosol — Reduces LDL oxidation ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Hydroxytyrosol and "Reduces LDL oxidation". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Hydroxytyrosol — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Hydroxytyrosol and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Hydroxytyrosol — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Hydroxytyrosol and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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