Magnesium Deficiency
Cramping, sleep, and BP implications.
Ranked by evidence strength across reported benefits.
Magnesium
Essential cofactor in 300+ enzymatic reactions, from ATP production to muscle relaxation.
Ashwagandha
Adaptogenic herb that down-regulates HPA-axis output — lowers cortisol, supports T in stressed men.
Melatonin
Pineal hormone that signals biological night — most effective for circadian-rhythm shifts.
L-Theanine
Calm focus — alpha-wave amino acid from green tea that takes the edge off caffeine.
Magnesium Glycinate
Chelated magnesium bound to glycine — best-tolerated form for sleep, calm, and muscle relaxation.
CBD (Cannabidiol)
Non-intoxicating cannabinoid studied for anxiety, sleep, and seizures.
Glycine
Inhibitory amino acid that improves sleep quality, glycemic control, and collagen synthesis.
Bacopa Monnieri
Ayurvedic nootropic with strong evidence for memory consolidation over 8–12 weeks.
Melatonin (low-dose physiologic)
Endogenous sleep hormone; low doses (0.3–0.5 mg) typically outperform mega-doses.
Lavender Oil (Silexan)
Oral lavender essential oil with proven anxiolytic effect.
Kava (WS-1490)
Standardized kavalactone extract for anxiety.
Chamomile (GAD)
Matricaria recutita standardized extract for generalized anxiety.
Rhodiola Rosea
Arctic adaptogen — reduces fatigue and improves mental performance under stress.
Glycine
Inhibitory neurotransmitter that improves sleep quality and supports collagen synthesis.
Panax Ginseng
Adaptogenic ginseng studied for fatigue, cognition, and erectile function.
Holy Basil (Tulsi)
Ayurvedic adaptogen with anti-stress, anti-inflammatory, and glycemic effects.
Licorice Root
Adrenal-supporting herb; chronic high-dose causes pseudo-aldosteronism.
Phosphatidylserine (PS)
Phospholipid that supports cognition and may blunt cortisol response to stress.
Tongkat Ali (Eurycoma longifolia)
Malaysian root with moderate human evidence for raising free testosterone and reducing SHBG.
KSM-66 Ashwagandha
Root-only standardized ashwagandha extract — the most-studied form for stress and T-support.
Passionflower
Mild anxiolytic and sleep aid with GABA-A modulation.
Reishi
Adaptogenic mushroom used for immune balance, sleep, and stress.
Magnesium L-Threonate
Magnesium bound to L-threonic acid — the only form shown to meaningfully raise brain magnesium.
Passionflower (Anxiety)
Passiflora incarnata for mild GAD and pre-surgical anxiety.
L-Tyrosine
Catecholamine precursor preserving cognition under stress and sleep deprivation.
L-Tryptophan
Essential amino acid precursor to serotonin and melatonin.
Chamomile
Gentle anxiolytic and sleep-supportive herb.
Lemon Balm
Mild anxiolytic with cognitive calming effects via GABA-T inhibition.
Schisandra
Adaptogenic berry traditionally used for stamina, liver protection, and stress resilience.
Magnesium Glycinate
Bisglycinate chelate form of magnesium — gentle, well-absorbed, ideal for sleep.
Glycine (Sleep Onset)
3 g pre-bed lowers core body temperature and improves subjective sleep.
Ashwagandha (Cortisol Lowering)
Validated cortisol-lowering adaptogen — ~28% reduction in chronically stressed adults.
Sensoril Ashwagandha
Root + leaf extract standardized to ≥10% withanolides — higher potency, more sedating.
Magnolia Bark
GABAergic anxiolytic bark extract used for sleep and stress.
Hops Extract
Bitter cone extract with mild sedative and phytoestrogenic effects.
L-Tryptophan (Sleep)
Direct serotonin/melatonin precursor for nocturnal use.
GABA (Pharma-grade)
Fermented GABA with reported peripheral relaxation effects.
Valerian (Sleep)
Valeriana officinalis root extract for sleep latency.
California Poppy
Eschscholzia californica for anxiety and insomnia.
Shoden Ashwagandha
35% withanolide glycoside Ashwagandha for sleep.
Poria Cocos
TCM mushroom for sleep and immunity.
PharmaGABA
Naturally fermented GABA.
Zinc Monomethionine (ZMA)
Zinc + magnesium + B6 for recovery.
Saffron Affron
Standardized saffron for mood.
Valerian Root Extract
Valeriana officinalis for sleep.
Valerian + Hops
Sleep blend.
Honokiol
Active magnolia compound.
Micellar Casein
Slow-digesting milk protein.
5-HTP
Direct serotonin precursor with mood and sleep applications.
Eleuthero
Adaptogen used to support stamina, immune function, and stress resilience.
Magnesium Taurate
Magnesium + taurine — gentle on the gut with cardiovascular and glycemic synergies.
GABA
Primary inhibitory neurotransmitter; oral supplementation has limited CNS penetration.
Valerian Root
Sedative herb traditionally used for sleep onset and mild anxiety.
Phenibut (caution)
GABA-B agonist with high abuse and dependence potential; restricted in many countries.
Magnesium L-Threonate
Mg form designed for brain penetration; studied for cognition and sleep.
Ashwagandha (Thyroid Support)
Supports T4→T3 conversion in subclinical hypothyroid adults.
L-Ornithine
Urea-cycle amino acid that lowers fatigue and supports nighttime GH release.
Valerian Root
GABAergic sedative herb — modest sleep onset benefit.
California Poppy
Mild sedative with anxiolytic and analgesic activity.
Ziziphus (Jujube Seed)
Traditional Chinese seed extract for insomnia and anxiety.