Supplement Scholar
Goal area

Immune & Inflammation

Innate immunity, cytokines, and infection support.

106 profiles, most-studied first
C27H44O

Vitamin D3

Steroid hormone precursor regulating ~5% of the human genome — bone, immune, and hormonal health.

Vitamin12 studies
C60H92O6

Omega-3 (EPA/DHA)

Marine long-chain omega-3s — the most-studied anti-inflammatory and cardiovascular nutrient.

Fatty Acid11 studies
C21H20O6

Curcumin

Yellow polyphenol from turmeric — anti-inflammatory and joint-supportive when properly bioavailable.

Herb10 studies
C17H26O4

Ginger

Culinary rhizome with strong antiemetic and anti-inflammatory effects.

Herb10 studies
C5H9NO3S

N-Acetyl Cysteine (NAC)

Glutathione precursor with mucolytic, hepatoprotective, and psychiatric uses.

Amino Acid10 studies
Zn

Zinc

Cofactor for ~300 enzymes — critical for testosterone, immune function, and DNA synthesis.

Mineral10 studies
C54H92O23

American Ginseng

Cooler adaptogen with stronger evidence for blood sugar and cold-flu prevention.

Herb9 studies
C40H52O4

Astaxanthin

Algae-derived xanthophyll — most potent natural antioxidant; UV/eye/skin support.

Compound9 studies
C18H32O16

Beta-Glucan

Polysaccharide that primes innate immune cells (yeast) or lowers cholesterol (oat).

Compound9 studies
C32H48O5

Boswellia

Anti-inflammatory resin used for osteoarthritis and IBD.

Herb9 studies

Bovine Colostrum

First milk rich in IgG, lactoferrin, and growth factors for immune and gut support.

Compound9 studies

Bromelain

Pineapple proteolytic enzyme with anti-inflammatory and fibrinolytic effects.

Compound9 studies
C21H30O2

CBD (Cannabidiol)

Non-intoxicating cannabinoid studied for anxiety, sleep, and seizures.

Compound9 studies
C18H27NO3

Capsaicin

Chili pepper compound that mildly increases thermogenesis and reduces appetite.

Compound9 studies
C34H46O18

Eleuthero

Adaptogen used to support stamina, immune function, and stress resilience.

Herb9 studies
C18H30O2

Evening Primrose Oil

Omega-6 source rich in GLA, used for atopic dermatitis and cyclical breast pain.

Fatty Acid9 studies
C6H10OS2

Garlic

Culinary bulb with cardiovascular benefits primarily via allicin and aged-garlic compounds.

Herb9 studies
C5H10N2O3

L-Glutamine

Most abundant amino acid; primary fuel for enterocytes and immune cells.

Amino Acid9 studies

Lactobacillus Probiotics

Lactic acid bacteria supporting gut barrier, immunity, and women's urogenital health.

Compound9 studies

Lactoferrin

Iron-binding protein with antimicrobial and immunomodulating effects.

Compound9 studies
C42H62O16

Licorice Root

Adrenal-supporting herb; chronic high-dose causes pseudo-aldosteronism.

Herb9 studies
C25H22O10

Milk Thistle (Liver)

Silymarin — most-studied liver herb, used for ALD, NAFLD, and toxin protection.

Herb9 studies

Multi-Strain Probiotic

Live bacterial supplement — strain-specific effects on digestion, immunity, and mood.

Compound9 studies
C15H10O7

Quercetin

Flavonoid with antihistamine and senolytic effects; pairs with bromelain or vitamin C.

Compound9 studies
C30H44O7

Reishi

Adaptogenic mushroom used for immune balance, sleep, and stress.

Mushroom9 studies
C33H38N4O6

Spirulina

Blue-green algae — protein-rich with phycocyanin antioxidant and immune effects.

Compound9 studies
C6H11NOS2

Sulforaphane (Broccoli Sprout)

Most potent natural Nrf2 activator — upregulates phase II detox enzymes.

Compound9 studies
C27H31ClO15

Tart Cherry (Montmorency)

Natural melatonin and anthocyanin source — improves sleep and reduces DOMS.

Compound9 studies
C20H30O

Vitamin A (Retinol)

Fat-soluble vitamin essential for vision, immune function, and epithelial integrity.

Vitamin9 studies
C6H8O6

Vitamin C

Water-soluble antioxidant, collagen cofactor, and immune supporter.

Vitamin9 studies
C28H44O

Agaricus Blazei

Brazilian sun mushroom for immune support.

Mushroom8 studies
C9H15N3O2S

Agaricus blazei

Brazilian mushroom rich in β-glucans for immune modulation.

Mushroom8 studies
C22H40O7

Agarikon (Fomitopsis officinalis)

Antiviral polypore mushroom.

Mushroom8 studies
C6H10OS2

Aged Garlic Extract (Kyolic)

Standardized aged garlic — modest BP and cholesterol benefits.

Herb8 studies
C34H22O22

Amla (Indian Gooseberry)

Phyllanthus emblica vitamin C source.

Herb8 studies
C20H30O5

Andrographis

Bitter herb with strong RCT evidence for URI symptom reduction.

Herb8 studies
C22H38O7

Ascorbyl Palmitate

Fat-soluble vitamin C ester.

Vitamin8 studies
C41H68O14

Astragalus

TCM tonic with immune-stimulating and CKD-supportive evidence.

Herb8 studies
C21H18O11

Baicalin

Scutellaria baicalensis flavonoid.

Compound8 studies
C27H30O16

Bee Pollen

Pollen collected by bees.

Compound8 studies

Bifidobacterium Probiotics

Dominant probiotic genus in the colon; supports immune and gut barrier.

Compound8 studies
C10H12O2

Black Cumin Seed Oil

Nigella sativa oil.

Fatty Acid8 studies
C10H12O2

Black Seed Oil (Nigella sativa)

Thymoquinone for immune and metabolic health.

Fatty Acid8 studies

Bovine Colostrum

First milk with growth factors.

Compound8 studies

Bromelain

Pineapple proteolytic enzyme.

Compound8 studies
C20H28O3

Butterbur

Petasites hybridus extract for migraine prophylaxis and allergic rhinitis.

Herb8 studies
C20H28O3

Butterbur Ze 339

PA-free butterbur for allergic rhinitis.

Herb8 studies

Calcium AEP (Membrane Calcium)

Cell-membrane-targeted form of calcium claimed for autoimmune support.

Mineral8 studies
C22H28N2O4

Cat's Claw

Uncaria tomentosa for joint pain and immunity.

Herb8 studies
C30H48O3

Chaga

Birch-tree mushroom rich in melanin, betulin, and antioxidants.

Mushroom8 studies
C21H18O11

Chinese Skullcap

Flavonoid-rich root used for anxiety and inflammation.

Herb8 studies
C55H72MgN4O5

Chlorella

Green algae with chlorophyll.

Compound8 studies
C10H13N5O3

Cordyceps

Medicinal fungus studied for aerobic capacity and immune modulation.

Mushroom8 studies
C30H24O12

Cranberry

Berry with PACs that inhibit E. coli adhesion to urothelium for UTI prevention.

Herb8 studies
C30H24O12

Cranberry (PAC-A)

Type-A proanthocyanidins prevent E. coli adhesion to bladder epithelium.

Compound8 studies
C30H24O12

Cranberry Extract

Vaccinium macrocarpon for UTI prevention.

Herb8 studies
C11H10O5

EPs 7630

Standardized Pelargonium extract.

Herb8 studies
C22H18O12

Echinacea

Native American herb used for URI prevention/duration reduction.

Herb8 studies
C22H18O12

Echinacea Angustifolia

Narrow-leaf coneflower for immune support.

Herb8 studies
C22H18O12

Echinacea Purpurea

Coneflower for upper respiratory infections.

Herb8 studies
C26H29ClO15

Elderberry

Anthocyanin-rich berry used to shorten influenza and URI symptoms.

Herb8 studies
C9H15N3O2S

Ergothioneine

Unique antioxidant from mushrooms with its own transporter — accumulates in oxidative-stress tissues.

Compound8 studies
C15H10O5

Galangal (Alpinia)

Thai ginger relative for inflammation.

Herb8 studies
C17H26O4

Ginger Extract (Zingiber)

Standardized ginger for nausea and inflammation.

Herb8 studies
C5H9NO3S

GlyNAC (Glycine + NAC)

Glycine + NAC combo — restores glutathione in older adults and improves multiple aging markers.

Amino Acid8 studies
C6H8O8

Hibiscus Tea

Anthocyanin-rich tea with ACE-inhibitor-like blood pressure effects.

Herb8 studies
C10H12O2

Holy Basil (Tulsi)

Ocimum sanctum adaptogen.

Herb8 studies
C10H12O2

Holy Basil Eugenol

Active constituent of tulsi.

Compound8 studies
C21H20O12

Isoquercetin

Highly bioavailable quercetin glycoside.

Compound8 studies
C9H14N4O3

L-Carnosine

Histidine dipeptide — anti-glycation and pH buffering.

Amino Acid8 studies
C6H14N2O2

L-Lysine

Essential amino acid for collagen and HSV prevention.

Amino Acid8 studies

Lactobacillus Rhamnosus GG

Most-studied single strain — atopy, pediatric diarrhea, and antibiotic recovery.

Compound8 studies
C12H24O2

Lauric Acid

Coconut MCFA with antimicrobial activity.

Fatty Acid8 studies
C25H36O6

Lion's Mane Fruiting Body

Hericinones-rich beta-glucan source.

Mushroom8 studies
C6H8O6

Liposomal Vitamin C

Phospholipid-encapsulated vitamin C.

Vitamin8 studies
C15H10O6

Luteolin

Flavone with anti-inflammatory effects.

Compound8 studies
C9H15N3O2S

Maitake D-Fraction

Standardized β-glucan from Grifola frondosa for immune support.

Mushroom8 studies
C3H4O2

Manuka Honey

Leptospermum honey with MGO.

Compound8 studies
C6H10O7

Marshmallow Root

Althaea officinalis mucilage for cough.

Herb8 studies
C15H30O4

Monolaurin

Coconut-derived monoglyceride with antimicrobial properties against enveloped viruses.

Compound8 studies
C5H9NO3S

NAC (Lung Support)

Mucolytic and antioxidant — used for COPD exacerbations and idiopathic pulmonary fibrosis.

Amino Acid8 studies
C10H14O

Oil of Oregano

Carvacrol-rich essential oil with broad antimicrobial activity (in vitro).

Herb8 studies
C25H32O13

Olive Leaf (Standardized Oleuropein)

High-oleuropein extract.

Herb8 studies
C25H32O13

Olive Leaf Extract

Mediterranean herb with antihypertensive and immune effects.

Herb8 studies
C24H36O5

Oyster Mushroom

Pleurotus ostreatus with ergothioneine.

Mushroom8 studies
C18H37NO2

PEA (Palmitoylethanolamide)

Endogenous fatty acid amide for pain and inflammation.

Compound8 studies
C11H10O5

Pelargonium Sidoides

South African geranium for bronchitis.

Herb8 studies
C11H10O5

Pelargonium sidoides (Umckaloabo)

South African geranium root for acute bronchitis and URIs.

Herb8 studies
C13H10O5

Phellinus Linteus

Meshima mushroom with hispolon for immune support.

Mushroom8 studies
C33H52O5

Poria Cocos

TCM mushroom for sleep and immunity.

Mushroom8 studies
C17H16O4

Propolis

Bee glue with caffeic acid phenethyl ester.

Compound8 studies
C15H10O7

Quercetin + Bromelain

Anti-inflammatory pair for allergies.

Compound8 studies
C15H10O7

Quercetin Phytosome

Lecithin-complexed quercetin.

Compound8 studies

Saccharomyces Boulardii

Beneficial yeast used to prevent and treat several types of diarrhea.

Compound8 studies
Se

Selenium

Trace mineral essential for glutathione peroxidase and thyroid hormone activation.

Mineral8 studies
Se

Selenium (Selenomethionine)

Antioxidant trace element for thyroid.

Mineral8 studies

Serrapeptase

Silkworm-derived proteolytic enzyme used for inflammation and fibrin breakdown.

Compound8 studies
C9H11N5O4

Shiitake (Lentinan)

Culinary mushroom whose beta-glucan lentinan is an approved injectable immune adjunct.

Mushroom8 studies
C6H7NaO6

Sodium Ascorbate

Buffered vitamin C form.

Vitamin8 studies
C29H50O

Stinging Nettle Leaf

Urtica dioica leaf for allergies and joint pain.

Herb8 studies
C10H12O2

Thymoquinone

Active black seed compound.

Compound8 studies
C33H54N12O15

Thymulin (Reference)

Zinc-dependent thymic peptide that matures T-cells.

Peptide8 studies
C28H44O

Turkey Tail

Beta-glucan-rich mushroom used as immune adjunct in cancer (PSK approved in Japan).

Mushroom8 studies
C6H8O6

Vitamin C (Harm-Reduction Antioxidant)

Water-soluble antioxidant — quenches dopamine quinone and other reactive metabolites.

Vitamin8 studies
C6H8O6

Vitamin C (Immune Use)

High-dose vit C at symptom onset — modestly shortens cold duration.

Vitamin8 studies
Zn

Zinc (Immune Use)

Lozenges started within 24h of symptom onset shorten colds ~33%.

Mineral8 studies