Supplement Scholar
Compound

Luteolin

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Luteolin. Flavone with anti-inflammatory effects.

How it works. Inhibits mast cell activation; PDE inhibitor.

What the research supports. 1 graded claims. Strongest: Reduces neuroinflammation (preclinical) (moderate).

How much to take. Typical dose: 100 mg.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Omega-3 (EPA/DHA), Alpha-GPC or CDP-choline, Vitamin D3 + K2.

Common forms. Available as Capsule or softgel, Powder, Sublingual or buccal, Liposomal liquid.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Luteolin. Anecdotes are not medical advice.

Luteolin. Flavone with anti-inflammatory effects.

Molecular structureC15H10O6 · 286.24 g/mol

What it is

Flavone with anti-inflammatory effects.

Food sources

Endogenously produced or biosynthesized moleculeStandardized pharmaceutical- or food-grade supplementCombined with cofactors that improve absorption or activity

Goals

Brain & CognitiveImmune Function

How it works

Inhibits mast cell activation; PDE inhibitor.

Pathways

  • Inhibits mast cell activation
  • PDE inhibitor

Effects

  • ↓neuroinflammation (preclinical) decreases

What the research supports

Reduces neuroinflammation (preclinical)moderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
100 mg
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodWith a meal containing fat for fat-soluble compounds; otherwise either.
Best formMost evidence is based on the capsule or softgel form.
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Side effects & interactions

Common side effects

  • Well tolerated

Medication interactions

Prescription medications (general)minor

Always disclose Luteolin use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Omega-3 (EPA/DHA)Membrane fluidity and neuronal signaling support.
  • Alpha-GPC or CDP-cholineProvides choline substrate for acetylcholine synthesis.
  • Vitamin D3 + K2Foundational immune modulation.

Common forms

  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Key studies

8 studies cited in total.

PubMed: Luteolin — Reduces neuroinflammation ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Luteolin and "Reduces neuroinflammation". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Luteolin — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Luteolin and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Luteolin — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Luteolin and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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