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Butterbur Ze 339

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Butterbur Ze 339. PA-free butterbur for allergic rhinitis.

How it works. Inhibits leukotrienes; histamine blocker.

What the research supports. 1 graded claims. Strongest: Reduces hay fever (moderate).

How much to take. Typical dose: 8 mg TID.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Vitamin D3 + K2, Zinc.

Common forms. Available as Standardized extract capsule, Liquid tincture (alcohol or glycerin), Powdered whole herb, Traditional decoction or tea.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Butterbur Ze 339. Anecdotes are not medical advice.

Butterbur Ze 339. PA-free butterbur for allergic rhinitis.

Key compound: petasinC20H28O3 · 316.4 g/mol

What it is

PA-free butterbur for allergic rhinitis.

Food sources

Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice

Goals

Immune Function

How it works

Inhibits leukotrienes; histamine blocker.

Pathways

  • Inhibits leukotrienes
  • histamine blocker

Effects

  • ↓hay fever decreases

What the research supports

Reduces hay fevermoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
8 mg TID
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodEither with or without food.
Best formMost evidence is based on the standardized extract capsule form.
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Side effects & interactions

Common side effects

  • GI upset

Medication interactions

Prescription medications (general)minor

Always disclose Butterbur Ze 339 use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Vitamin D3 + K2Foundational immune modulation.
  • ZincRequired cofactor for innate and adaptive immune function.

Common forms

  • Standardized extract capsule
  • Liquid tincture (alcohol or glycerin)
  • Powdered whole herb
  • Traditional decoction or tea

Key studies

8 studies cited in total.

PubMed: Butterbur Ze 339 — Reduces hay fever ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Butterbur Ze 339 and "Reduces hay fever". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Butterbur Ze 339 — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Butterbur Ze 339 and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Butterbur Ze 339 — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Butterbur Ze 339 and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

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