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Compound

CBD (Cannabidiol)

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CBD (Cannabidiol). Non-intoxicating cannabinoid studied for anxiety, sleep, and seizures.

How it works. Modulates endocannabinoid tone (FAAH inhibition) and 5-HT1A receptors.

What the research supports. 2 graded claims. Strongest: Reduces seizures in Dravet/LGS (Epidiolex) (strong).

How much to take. Typical dose: 25–75 mg/d general; Epidiolex 10 mg/kg.

Side effects and interactions. 2 medication interactions listed. Serious: Hepatotoxicity at >20 mg/kg.

Stacking. Pairs well with Magnesium glycinate, L-theanine.

Common forms. Available as Full-spectrum oil, Broad spectrum, Isolate.

Key studies. 9 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried CBD (Cannabidiol). Anecdotes are not medical advice.

CBD (Cannabidiol). Non-intoxicating cannabinoid studied for anxiety, sleep, and seizures.

Molecular structureC21H30O2 · 314.5 g/mol

What it is

Non-intoxicating cannabinoid studied for anxiety, sleep, and seizures.

Food sources

Cannabis sativa / hemp

Goals

Mood & AnxietySleep & RecoveryChronic Inflammation

How it works

Modulates endocannabinoid tone (FAAH inhibition) and 5-HT1A receptors.

Pathways

  • FAAH inhibition
  • 5-HT1A modulation

Effects

  • ↓Anxiety decreases
  • ↓Seizure frequency (Dravet, LGS) decreases

What the research supports

Reduces seizures in Dravet/LGS (Epidiolex)strong
Reduces social anxiety symptomsmoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
25–75 mg/d general; Epidiolex 10 mg/kg
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodWith a meal containing fat for fat-soluble compounds; otherwise either.
Best formMost evidence is based on the full-spectrum oil form.
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Side effects & interactions

Common side effects

  • Drowsiness
  • Diarrhea
  • Appetite changes

Serious

  • Hepatotoxicity at >20 mg/kg

Medication interactions

Warfarin / clobazam / many CYP3A4 substratessevere

CYP inhibition.

Hepatotoxic drugsmoderate

Additive.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

Common forms

  • Full-spectrum oil
  • Broad spectrum
  • Isolate

Key studies

9 studies cited in total.

PubMed: CBD (Cannabidiol) — Reduces seizures in Dravet/LGS ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching CBD (Cannabidiol) and "Reduces seizures in Dravet/LGS". Filter by RCT, meta-analysis, or year on the results page.

PubMed: CBD (Cannabidiol) — Reduces social anxiety symptoms ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching CBD (Cannabidiol) and "Reduces social anxiety symptoms". Filter by RCT, meta-analysis, or year on the results page.

PubMed: CBD (Cannabidiol) — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching CBD (Cannabidiol) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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