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Mushroom

Agaricus Blazei

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Agaricus Blazei. Brazilian sun mushroom for immune support.

How it works. Beta-glucans and ergosterol modulate immunity.

What the research supports. 1 graded claims. Strongest: Increases NK cell activity (moderate).

How much to take. Typical dose: 1500 mg extract.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Vitamin D3 + K2, Zinc.

Common forms. Available as Capsule or softgel, Powder, Sublingual or buccal, Liposomal liquid.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Agaricus Blazei. Anecdotes are not medical advice.

Agaricus Blazei. Brazilian sun mushroom for immune support.

Key compound: ergosterolC28H44O · 396.6 g/mol

What it is

Brazilian sun mushroom for immune support.

Food sources

Endogenously produced or biosynthesized moleculeStandardized pharmaceutical- or food-grade supplementCombined with cofactors that improve absorption or activity

Goals

Immune Function

How it works

Beta-glucans and ergosterol modulate immunity.

Pathways

  • Beta-glucans
  • ergosterol modulate immunity

Effects

  • ↑NK cell activity increases

What the research supports

Increases NK cell activitymoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
1500 mg extract
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodEither with or without food.
Best formMost evidence is based on the capsule or softgel form.
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Side effects & interactions

Common side effects

  • GI upset
  • Hepatotoxicity case reports

Medication interactions

Prescription medications (general)minor

Always disclose Agaricus Blazei use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Vitamin D3 + K2Foundational immune modulation.
  • ZincRequired cofactor for innate and adaptive immune function.

Common forms

  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Key studies

8 studies cited in total.

PubMed: Agaricus Blazei — Increases NK cell activity ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Agaricus Blazei and "Increases NK cell activity". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Agaricus Blazei — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Agaricus Blazei and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Agaricus Blazei — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Agaricus Blazei and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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