Supplement Scholar
Compound

Holy Basil Eugenol

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Holy Basil Eugenol. Active constituent of tulsi.

How it works. COX inhibitor; antimicrobial.

What the research supports. 1 graded claims. Strongest: Pain and infection (moderate).

How much to take. Typical dose: Topical or 100 mg.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Vitamin D3 + K2, Zinc.

Common forms. Available as Capsule or softgel, Powder, Sublingual or buccal, Liposomal liquid.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Holy Basil Eugenol. Anecdotes are not medical advice.

Holy Basil Eugenol. Active constituent of tulsi.

Molecular structureC10H12O2 · 164.20 g/mol

What it is

Active constituent of tulsi.

Food sources

Endogenously produced or biosynthesized moleculeStandardized pharmaceutical- or food-grade supplementCombined with cofactors that improve absorption or activity

Goals

Immune Function

How it works

COX inhibitor; antimicrobial.

Pathways

  • COX inhibitor
  • antimicrobial

Effects

  • +Pain and infection supports

What the research supports

Pain and infectionmoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
Topical or 100 mg
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodWith a meal containing fat for fat-soluble compounds; otherwise either.
Best formMost evidence is based on the capsule or softgel form.
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Side effects & interactions

Common side effects

  • Hepatic at high dose

Medication interactions

Prescription medications (general)minor

Always disclose Holy Basil Eugenol use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Vitamin D3 + K2Foundational immune modulation.
  • ZincRequired cofactor for innate and adaptive immune function.

Common forms

  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Key studies

8 studies cited in total.

PubMed: Holy Basil Eugenol — Pain and infection ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Holy Basil Eugenol and "Pain and infection". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Holy Basil Eugenol — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Holy Basil Eugenol and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Holy Basil Eugenol — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Holy Basil Eugenol and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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