Evening Primrose Oil
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Evening Primrose Oil. Omega-6 source rich in GLA, used for atopic dermatitis and cyclical breast pain.
How it works. GLA converts to DGLA, producing anti-inflammatory PGE1.
What the research supports. 2 graded claims. Strongest: Modest improvement in cyclical breast pain (limited).
How much to take. Typical dose: 1000–3000 mg/d (8–10% GLA).
Side effects and interactions. 2 medication interactions listed. No serious side effects listed at normal doses.
Stacking. Pairs well with Collagen peptides, Vitamin C.
Common forms. Available as EPO standardized to GLA.
Key studies. 9 studies cited. The strongest are listed with links to PubMed.
Community. Experiences from people who have tried Evening Primrose Oil. Anecdotes are not medical advice.
Evening Primrose Oil. Omega-6 source rich in GLA, used for atopic dermatitis and cyclical breast pain.
What it is
Omega-6 source rich in GLA, used for atopic dermatitis and cyclical breast pain.
Also called
Food sources
Goals
How it works
GLA converts to DGLA, producing anti-inflammatory PGE1.
Pathways
- PGE1 synthesis
Effects
- +Skin barrier supports
- ↓Cyclical breast pain (mild) decreases
What the research supports
Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.
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Side effects & interactions
Common side effects
- GI upset
Medication interactions
Mild antiplatelet.
May lower threshold.
Check any supplement–medication combination with your pharmacist before starting.
Combines with
Pairs well
- Collagen peptidesProvides amino acid substrate for connective tissue synthesis.
- Vitamin CRequired cofactor for collagen hydroxylation.
Common forms
- EPO standardized to GLA
Key studies
9 studies cited in total.
Opens current human and preclinical literature matching Evening Primrose Oil and "Modest improvement in cyclical breast pain". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching Evening Primrose Oil and "Mixed for atopic dermatitis". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching Evening Primrose Oil and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.
Discussion
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