Serrapeptase
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Serrapeptase. Silkworm-derived proteolytic enzyme used for inflammation and fibrin breakdown.
How it works. Hydrolyzes fibrin and dead tissue.
What the research supports. 1 graded claims. Strongest: Limited but suggestive evidence for inflammatory conditions (limited).
How much to take. Typical dose: 10–60 mg enteric, empty stomach.
Side effects and interactions. 1 medication interaction listed. Serious: Pneumonitis case reports.
Stacking. Pairs well with A high-quality multivitamin, Omega-3 (EPA/DHA).
Forms. 1 forms. Pick one to open its profile.
Key studies. 8 studies cited. The strongest are listed with links to PubMed.
Community. Experiences from people who have tried Serrapeptase. Anecdotes are not medical advice.
Serrapeptase. Silkworm-derived proteolytic enzyme used for inflammation and fibrin breakdown.
What it is
Silkworm-derived proteolytic enzyme used for inflammation and fibrin breakdown.
Food sources
Goals
How it works
Hydrolyzes fibrin and dead tissue.
Pathways
- Fibrinolysis
Effects
- ↓Inflammation/edema decreases
What the research supports
Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.
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Side effects & interactions
Common side effects
- GI upset
Serious
- Pneumonitis case reports
Medication interactions
Fibrinolytic.
Check any supplement–medication combination with your pharmacist before starting.
Combines with
Pairs well
- A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
- Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.
Forms
Key studies
8 studies cited in total.
Opens current human and preclinical literature matching Serrapeptase and "Limited but suggestive evidence for inflammatory conditions". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching Serrapeptase and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching Serrapeptase and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.
Discussion
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