Longevity & Anti-Aging
Mitochondria, NAD+, senescence, and biological age.
Glycine + NAC (GlyNAC)
Co-supplementation of glycine and N-acetylcysteine that restores glutathione in older adults and improves multiple hallmarks of aging.
Melatonin
Pineal hormone that signals biological night — most effective for circadian-rhythm shifts.
Coenzyme Q10
Mitochondrial electron carrier and lipid-soluble antioxidant.
Coffee
Caffeine + polyphenol matrix with strong evidence for mortality and T2D reduction.
Glycine
Inhibitory neurotransmitter that improves sleep quality and supports collagen synthesis.
Lion's Mane
Edible medicinal mushroom that upregulates NGF and BDNF — studied for nerve growth and cognition.
N-Acetyl Cysteine (NAC)
Glutathione precursor with mucolytic, hepatoprotective, and psychiatric uses.
Vitamin K2 (MK-7)
Activates the proteins that direct calcium into bone — not arteries.
Alpha-Lipoic Acid (ALA)
Universal antioxidant that's both water and fat soluble — supports glycemic control and nerve health.
Astaxanthin
Algal carotenoid that is the strongest membrane antioxidant; UV and eye protection.
Calcium AKG (Alpha-Ketoglutarate)
TCA-cycle intermediate — extended lifespan in C. elegans; emerging human data on biological age.
DHEA
Adrenal androgen precursor declining with age; used for adrenal insufficiency and aging.
Fisetin
Flavonoid studied as senolytic — clearing senescent cells in animal models.
Garlic
Culinary bulb with cardiovascular benefits primarily via allicin and aged-garlic compounds.
Ginkgo Biloba
Vasoactive herb studied for cognition in the elderly and tinnitus.
Glutathione
Master intracellular antioxidant; oral bioavailability depends on form.
Green Tea (EGCG)
Polyphenol-rich tea; EGCG modestly boosts metabolism and supports cardiovascular health.
Metformin (Rx, reference)
Diabetes drug studied for longevity (TAME trial) via AMPK activation.
Milk Thistle
Hepatoprotective herb with antioxidant and anti-fibrotic effects.
NMN
NAD+ precursor similar to NR; bioavailability route debated.
Nicotinamide Riboside (NR)
NAD+ precursor with bioavailability and longevity research interest.
Pomegranate
Polyphenol-rich fruit converted by gut microbes to urolithin A (mitochondrial benefit).
Quercetin
Flavonoid with antihistamine and senolytic effects; pairs with bromelain or vitamin C.
Rapamycin (Rx, reference)
mTOR inhibitor — most validated geroprotector in animal models; not a supplement.
Reishi
Adaptogenic mushroom used for immune balance, sleep, and stress.
Shilajit
Himalayan mineral exudate rich in fulvic acid, studied for testosterone and fatigue.
Sulforaphane (Broccoli Sprout)
Most potent natural Nrf2 activator — upregulates phase II detox enzymes.
TUDCA
Bile acid with hepatoprotective effects and ER stress reduction.
Taurine
Conditionally essential amino acid involved in bile salt conjugation, osmoregulation, and cardiac function.
Vitamin B3 (Niacin)
NAD+ precursor; nicotinic acid form lowers LDL and raises HDL.
Vitamin C
Water-soluble antioxidant, collagen cofactor, and immune supporter.
Vitamin E
Primary lipid-phase antioxidant protecting membrane PUFAs.
9-Me-BC
β-carboline alkaloid that upregulates dopamine neurons in animal models.
ALCAR + ALA (Mitochondrial Protection)
Mitochondrial antioxidant stack — popularized as harm-reduction adjunct for MDMA neuroprotection.
Alpha-Ketoglutarate (AKG)
TCA-cycle intermediate studied for healthspan and frailty.
Alpha-Lipoic Acid
Mitochondrial antioxidant studied for diabetic neuropathy and insulin sensitivity.
Apigenin
Chamomile/parsley flavonoid — GABA-A modulator and CD38 inhibitor for sleep and NAD+.
C60 in Olive Oil
Buckminsterfullerene antioxidant.
Centrophenoxine
Cholinergic precursor that reduces lipofuscin accumulation in neurons.
Chaga
Birch-tree mushroom rich in melanin, betulin, and antioxidants.
EGCG (Green Tea Catechin)
Potent CYP/COMT-modulating antioxidant — popularized in MDMA harm-reduction stacks.
Ellagic Acid
Ellagitannin hydrolysis product.
Epitalon
Tetrapeptide that activates telomerase.
Ergothioneine
Unique antioxidant from mushrooms with its own transporter — accumulates in oxidative-stress tissues.
Ergothioneine (Mushroom-Derived)
Natural ergothioneine from oyster mushrooms.
GlyNAC (Glycine + NAC)
Glycine + NAC combo — restores glutathione in older adults and improves multiple aging markers.
Honokiol
Active magnolia compound.
Hydroxytyrosol
Olive polyphenol for cardiovascular health.
Idebenone
Synthetic CoQ10 analog with better water solubility; used in LHON.
Krill Oil
Phospholipid-bound omega-3 with astaxanthin; better bioavailability than fish oil per gram.
L-Carnosine
Histidine dipeptide — anti-glycation and pH buffering.
L-Carnosine
Dipeptide that buffers protons and reduces advanced glycation end-products.
Lithium Orotate (low-dose)
Low-dose lithium salt studied for mood stability and neuroprotection.
MOTS-c
Mitochondrial-derived peptide for metabolic regulation.
Metformin (Longevity Use)
Biguanide diabetes drug studied for healthspan.
Micronized Resveratrol
Improved bioavailability resveratrol.
MitoQ
Mitochondria-targeted ubiquinone (CoQ10 analog).
Oleocanthal
EVOO ibuprofen-like compound.
PQQ
Cofactor stimulating mitochondrial biogenesis (PGC-1α).
PQQ (Pyrroloquinoline Quinone)
Redox cofactor for mitochondrial biogenesis.
Pterostilbene
Bioavailable resveratrol analog with longer half-life.
Punicalagin
Major pomegranate ellagitannin.
Rapamycin
mTOR inhibitor studied for longevity (Rx only).
Resveratrol
Polyphenol activating sirtuins; bioavailability and clinical effects modest.
SS-31 (Elamipretide)
Mitochondrial-targeted peptide for cardiolipin protection.
Selenium
Trace mineral essential for glutathione peroxidase and thyroid hormone activation.
Selenium (Selenomethionine)
Antioxidant trace element for thyroid.
Spermidine
Polyamine inducing autophagy; epidemiologic association with longevity.
Thymulin (Reference)
Zinc-dependent thymic peptide that matures T-cells.
Trans-Resveratrol
Active form of resveratrol.
Urolithin A
Gut-microbial metabolite of ellagitannins — induces mitophagy.