Fisetin
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Fisetin. Flavonoid studied as senolytic — clearing senescent cells in animal models.
How it works. Selectively induces apoptosis in senescent cells (senolytic).
What the research supports. 2 graded claims. Strongest: Senolytic in animal models (limited).
How much to take. Typical dose: 100 mg/d general; 1500 mg × 2 days/month (senolytic protocol).
Side effects and interactions. 1 medication interaction listed. Serious: Discontinue and seek medical advice if symptoms are severe, persistent, or include difficulty breathing.
Stacking. Pairs well with NAD+ precursor (NMN or NR), Omega-3.
Forms. 1 forms. Pick one to open its profile.
Key studies. 9 studies cited. The strongest are listed with links to PubMed.
Community. Experiences from people who have tried Fisetin. Anecdotes are not medical advice.
Fisetin. Flavonoid studied as senolytic — clearing senescent cells in animal models.
What it is
Flavonoid studied as senolytic — clearing senescent cells in animal models.
Food sources
Goals
How it works
Selectively induces apoptosis in senescent cells (senolytic).
Pathways
- Senolysis
Effects
- ↓Senescent cell burden (animal) decreases
What the research supports
Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.
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Side effects & interactions
Common side effects
- Fisetin is generally well-tolerated at evidence-based doses
- Mild GI discomfort (nausea, loose stools, or bloating) possible at higher intakes
- Headache or transient fatigue reported by a small fraction of users
Serious
- Discontinue and seek medical advice if symptoms are severe, persistent, or include difficulty breathing
Medication interactions
Always disclose Fisetin use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
Check any supplement–medication combination with your pharmacist before starting.
Combines with
Pairs well
- NAD+ precursor (NMN or NR)Complementary mitochondrial and sirtuin support.
- Omega-3Lowers inflammation and supports membrane integrity.
Forms
Key studies
9 studies cited in total.
Opens current human and preclinical literature matching Fisetin and "Senolytic in animal models". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching Fisetin and "Human trials underway". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching Fisetin and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.
Discussion
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