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Compound

Fisetin (Senolytic)

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Fisetin (Senolytic). Polyphenol senolytic with neuroprotective and anti-inflammatory effects.

How it works. Clears senescent cells via Bcl-2 family modulation; activates Nrf2.

What the research supports. 1 graded claims. Strongest: Reduces senescent cell burden in animals (limited).

How much to take. Typical dose: 100 mg (daily) or 20 mg/kg pulsed (research).

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with NAD+ precursor (NMN or NR), Omega-3, Omega-3 (EPA/DHA).

Common forms. Available as Capsule or softgel, Powder, Sublingual or buccal, Liposomal liquid.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Fisetin (Senolytic). Anecdotes are not medical advice.

Fisetin (Senolytic). Polyphenol senolytic with neuroprotective and anti-inflammatory effects.

Molecular structureC15H10O6 · 286.24 g/mol

What it is

Polyphenol senolytic with neuroprotective and anti-inflammatory effects.

Food sources

Endogenously produced or biosynthesized moleculeStandardized pharmaceutical- or food-grade supplementCombined with cofactors that improve absorption or activity

Goals

Healthy AgingBrain & Cognitive

How it works

Clears senescent cells via Bcl-2 family modulation; activates Nrf2.

Pathways

  • Clears senescent cells via Bcl-2 family modulation
  • activates Nrf2

Effects

  • ↓senescent cell burden in animals decreases

What the research supports

Reduces senescent cell burden in animalslimited

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
100 mg (daily) or 20 mg/kg pulsed (research)
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodWith fat
Best formMost evidence is based on the capsule or softgel form.
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Side effects & interactions

Common side effects

  • GI upset

Medication interactions

Prescription medications (general)minor

Always disclose Fisetin (Senolytic) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • NAD+ precursor (NMN or NR)Complementary mitochondrial and sirtuin support.
  • Omega-3Lowers inflammation and supports membrane integrity.
  • Omega-3 (EPA/DHA)Membrane fluidity and neuronal signaling support.

Common forms

  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Key studies

8 studies cited in total.

PubMed: Fisetin (Senolytic) — Reduces senescent cell burden in animals ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Fisetin (Senolytic) and "Reduces senescent cell burden in animals". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Fisetin (Senolytic) — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Fisetin (Senolytic) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Fisetin (Senolytic) — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Fisetin (Senolytic) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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