Longevity & Anti-Aging
Longevity Pathways
mTOR, AMPK, SIRT, and autophagy.
7 profiles, most-studied first
C5H6O5
Calcium AKG (Alpha-Ketoglutarate)
TCA-cycle intermediate — extended lifespan in C. elegans; emerging human data on biological age.
Compound9 studies
C4H11N5
Metformin (Rx, reference)
Diabetes drug studied for longevity (TAME trial) via AMPK activation.
Compound9 studies
C51H79NO13
Rapamycin (Rx, reference)
mTOR inhibitor — most validated geroprotector in animal models; not a supplement.
Compound9 studies
C6H11NOS2
Sulforaphane (Broccoli Sprout)
Most potent natural Nrf2 activator — upregulates phase II detox enzymes.
Compound9 studies
C9H15N3O2S
Ergothioneine
Unique antioxidant from mushrooms with its own transporter — accumulates in oxidative-stress tissues.
Compound8 studies
C5H9NO3S
GlyNAC (Glycine + NAC)
Glycine + NAC combo — restores glutathione in older adults and improves multiple aging markers.
Amino Acid8 studies
C9H14N4O3
L-Carnosine
Histidine dipeptide — anti-glycation and pH buffering.
Amino Acid8 studies