Supplement Scholar
Compound

Rapamycin (Rx, reference)

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Prescription drug or research compound. Use only under the care of a licensed prescriber. Information here is educational and not a recommendation to obtain or use it.

Rapamycin (Rx, reference). mTOR inhibitor — most validated geroprotector in animal models; not a supplement.

How it works. Selectively inhibits mTORC1, mimicking caloric restriction signaling.

What the research supports. 2 graded claims. Strongest: Extends median/maximal lifespan in mice across strains (strong).

How much to take. Typical dose: Off-label longevity protocols: 5–6 mg weekly (Rx, MD supervision).

Side effects and interactions. 1 medication interaction listed. Serious: Infection risk.

Stacking. Pairs well with A high-quality multivitamin, Omega-3 (EPA/DHA).

Common forms. Available as Capsule or softgel, Powder, Sublingual or buccal, Liposomal liquid.

Key studies. 9 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Rapamycin (Rx, reference). Anecdotes are not medical advice.

Rapamycin (Rx, reference). mTOR inhibitor — most validated geroprotector in animal models; not a supplement.

Molecular structureC51H79NO13 · 914.2 g/mol

What it is

mTOR inhibitor — most validated geroprotector in animal models; not a supplement.

Food sources

Endogenously produced or biosynthesized moleculeStandardized pharmaceutical- or food-grade supplementCombined with cofactors that improve absorption or activity

Goals

Longevity PathwaysHealthy Aging (alias)Biological Age

How it works

Selectively inhibits mTORC1, mimicking caloric restriction signaling.

Pathways

  • Selectively inhibits mTORC1, mimicking caloric restriction signaling

Effects

  • +Extends median/maximal lifespan in mice across strains supports
  • +Human longevity unproven supports

What the research supports

Extends median/maximal lifespan in mice across strainsstrong
Human longevity unprovenlimited

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
Off-label longevity protocols: 5–6 mg weekly (Rx, MD supervision)
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodEmpty stomach
Best formMost evidence is based on the capsule or softgel form.
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Side effects & interactions

Common side effects

  • Mouth sores
  • Glucose intolerance

Serious

  • Infection risk

Medication interactions

Most CYP3A4 substratessevere

Major interaction risk.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
  • Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.

Common forms

  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Key studies

9 studies cited in total.

PubMed: Rapamycin (Rx, reference) — Extends median/maximal lifespan in mice across strains ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Rapamycin (Rx, reference) and "Extends median/maximal lifespan in mice across strains". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Rapamycin (Rx, reference) — Human longevity unproven ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Rapamycin (Rx, reference) and "Human longevity unproven". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Rapamycin (Rx, reference) — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Rapamycin (Rx, reference) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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