Calcium AKG (Alpha-Ketoglutarate)
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Calcium AKG (Alpha-Ketoglutarate). TCA-cycle intermediate — extended lifespan in C. elegans; emerging human data on biological age.
How it works. Co-substrate for α-KG-dependent dioxygenases (TET, JMJD); modulates DNA/histone demethylation.
What the research supports. 2 graded claims. Strongest: Lifespan extension in C. elegans/mice (moderate).
How much to take. Typical dose: 1000 mg Ca-AKG /d (sustained-release).
Side effects and interactions. 1 medication interaction listed. Serious: Discontinue and seek medical advice if symptoms are severe, persistent, or include difficulty breathing.
Stacking. Pairs well with A high-quality multivitamin, Omega-3 (EPA/DHA).
Common forms. Available as Capsule or softgel, Powder, Sublingual or buccal, Liposomal liquid.
Key studies. 9 studies cited. The strongest are listed with links to PubMed.
Community. Experiences from people who have tried Calcium AKG (Alpha-Ketoglutarate). Anecdotes are not medical advice.
Calcium AKG (Alpha-Ketoglutarate). TCA-cycle intermediate — extended lifespan in C. elegans; emerging human data on biological age.
What it is
TCA-cycle intermediate — extended lifespan in C. elegans; emerging human data on biological age.
Food sources
Goals
How it works
Co-substrate for α-KG-dependent dioxygenases (TET, JMJD); modulates DNA/histone demethylation.
Pathways
- Co-substrate for α-KG-dependent dioxygenases (TET, JMJD)
- modulates DNA/histone demethylation
Effects
- +Reduced biological age 8y in 7 months (open-label TruDiagnostic) supports
- +Lifespan extension in C. elegans/mice supports
What the research supports
Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.
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Side effects & interactions
Common side effects
- Calcium AKG (Alpha-Ketoglutarate) is generally well-tolerated at evidence-based doses
- Mild GI discomfort (nausea, loose stools, or bloating) possible at higher intakes
- Headache or transient fatigue reported by a small fraction of users
Serious
- Discontinue and seek medical advice if symptoms are severe, persistent, or include difficulty breathing
Medication interactions
Always disclose Calcium AKG (Alpha-Ketoglutarate) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
Check any supplement–medication combination with your pharmacist before starting.
Combines with
Pairs well
- A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
- Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.
Common forms
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Key studies
9 studies cited in total.
Opens current human and preclinical literature matching Calcium AKG (Alpha-Ketoglutarate) and "Reduced biological age 8y in 7 months". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching Calcium AKG (Alpha-Ketoglutarate) and "Lifespan extension in C. elegans/mice". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching Calcium AKG (Alpha-Ketoglutarate) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.
Discussion
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