Supplement Scholar
Compound

Metformin (Longevity Use)

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Prescription drug or research compound. Use only under the care of a licensed prescriber. Information here is educational and not a recommendation to obtain or use it.

Metformin (Longevity Use). Biguanide diabetes drug studied for healthspan.

How it works. Inhibits mitochondrial complex I; activates AMPK.

What the research supports. 1 graded claims. Strongest: May reduce age-related diseases (moderate).

How much to take. Typical dose: 500–1500 mg (Rx only).

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with NAD+ precursor (NMN or NR), Omega-3.

Common forms. Available as Capsule or softgel, Powder, Sublingual or buccal, Liposomal liquid.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Metformin (Longevity Use). Anecdotes are not medical advice.

Metformin (Longevity Use). Biguanide diabetes drug studied for healthspan.

Molecular structureC4H11N5 · 129.16 g/mol

What it is

Biguanide diabetes drug studied for healthspan.

Food sources

Endogenously produced or biosynthesized moleculeStandardized pharmaceutical- or food-grade supplementCombined with cofactors that improve absorption or activity

Goals

Healthy Aging

How it works

Inhibits mitochondrial complex I; activates AMPK.

Pathways

  • Inhibits mitochondrial complex I
  • activates AMPK

Effects

  • +May reduce age-related diseases supports

What the research supports

May reduce age-related diseasesmoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
500–1500 mg (Rx only)
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodWith a meal containing fat for fat-soluble compounds; otherwise either.
Best formMost evidence is based on the capsule or softgel form.
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Side effects & interactions

Common side effects

  • GI upset
  • B12 deficiency
  • Lactic acidosis (rare)

Medication interactions

Prescription medications (general)minor

Always disclose Metformin (Longevity Use) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • NAD+ precursor (NMN or NR)Complementary mitochondrial and sirtuin support.
  • Omega-3Lowers inflammation and supports membrane integrity.

Common forms

  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Key studies

8 studies cited in total.

PubMed: Metformin (Longevity Use) — May reduce age-related diseases ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Metformin (Longevity Use) and "May reduce age-related diseases". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Metformin (Longevity Use) — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Metformin (Longevity Use) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Metformin (Longevity Use) — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Metformin (Longevity Use) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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