Glycine
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Glycine. Inhibitory neurotransmitter that improves sleep quality and supports collagen synthesis.
How it works. Activates inhibitory glycine receptors and NMDA glycine site; lowers core body temperature via peripheral vasodilation.
What the research supports. 2 graded claims. Strongest: Improves subjective sleep quality (moderate).
How much to take. Typical dose: 3 g before bed. 30 min before bed.
Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.
Stacking. Pairs well with NAC.
Forms. 1 forms. Pick one to open its profile.
Key studies. 10 studies cited. The strongest are listed with links to PubMed.
Community. Experiences from people who have tried Glycine. Anecdotes are not medical advice.
Glycine. Inhibitory neurotransmitter that improves sleep quality and supports collagen synthesis.
What it is
Smallest amino acid; inhibitory in brainstem/spinal cord; precursor for collagen, glutathione, and creatine.
Food sources
Goals
How it works
Activates inhibitory glycine receptors and NMDA glycine site; lowers core body temperature via peripheral vasodilation.
Pathways
- Glycine receptor agonism
- NMDA co-agonism
Effects
- ↑Sleep quality (subjective) increases
- ↓Core body temperature decreases
- +Collagen synthesis supports
What the research supports
Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.
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Side effects & interactions
Common side effects
- Mild GI upset at high doses
Medication interactions
May reduce efficacy.
Check any supplement–medication combination with your pharmacist before starting.
Combines with
Pairs well
- NACBoth rate-limiting for glutathione synthesis.
Forms
Key studies
10 studies cited in total.
Opens current human and preclinical literature matching Glycine and "Improves subjective sleep quality". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching Glycine and "Improves daytime alertness after restricted sleep". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching Glycine and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.
Discussion
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