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Amino Acid

Ergothioneine (Mushroom-Derived)

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Ergothioneine (Mushroom-Derived). Natural ergothioneine from oyster mushrooms.

How it works. Same as synthetic; OCTN1 substrate.

What the research supports. 1 graded claims. Strongest: Antioxidant (moderate).

How much to take. Typical dose: 5 mg.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with NAD+ precursor (NMN or NR), Omega-3, Omega-3 (EPA/DHA).

Common forms. Available as Free-form crystalline powder, Capsules or tablets, Pre-mixed recovery or hydration beverages, Time-release formulations.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Ergothioneine (Mushroom-Derived). Anecdotes are not medical advice.

Ergothioneine (Mushroom-Derived). Natural ergothioneine from oyster mushrooms.

Molecular structureC9H15N3O2S · 229.30 g/mol

What it is

Natural ergothioneine from oyster mushrooms.

Food sources

Dietary protein from animal sources (meat, fish, eggs, dairy) and plant sources (soy, legumes, grains)Free-form amino acid powders and capsulesTargeted pre-workout, recovery, or sleep formulations

Goals

Healthy AgingBrain & Cognitive

How it works

Same as synthetic; OCTN1 substrate.

Pathways

  • Same as synthetic
  • OCTN1 substrate

Effects

  • +Antioxidant supports

What the research supports

Antioxidantmoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
5 mg
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodEither with or without food.
Best formMost evidence is based on the free-form crystalline powder form.
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Side effects & interactions

Common side effects

  • Well tolerated

Medication interactions

Prescription medications (general)minor

Always disclose Ergothioneine (Mushroom-Derived) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • NAD+ precursor (NMN or NR)Complementary mitochondrial and sirtuin support.
  • Omega-3Lowers inflammation and supports membrane integrity.
  • Omega-3 (EPA/DHA)Membrane fluidity and neuronal signaling support.

Common forms

  • Free-form crystalline powder
  • Capsules or tablets
  • Pre-mixed recovery or hydration beverages
  • Time-release formulations

Key studies

8 studies cited in total.

PubMed: Ergothioneine (Mushroom-Derived) — Antioxidant ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Ergothioneine (Mushroom-Derived) and "Antioxidant". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Ergothioneine (Mushroom-Derived) — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Ergothioneine (Mushroom-Derived) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Ergothioneine (Mushroom-Derived) — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Ergothioneine (Mushroom-Derived) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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