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Nootropic

Centrophenoxine

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Centrophenoxine. Cholinergic precursor that reduces lipofuscin accumulation in neurons.

How it works. Hydrolyzed to DMAE and pCPA; raises brain acetylcholine and removes lipofuscin deposits.

What the research supports. 1 graded claims. Strongest: Modest cognitive improvement in dementia (limited).

How much to take. Typical dose: 250–1000 mg.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Omega-3 (EPA/DHA), Alpha-GPC or CDP-choline, NAD+ precursor (NMN or NR).

Common forms. Available as Capsule, Powder for stacking, Sublingual tablet, Liposomal liquid.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Centrophenoxine. Anecdotes are not medical advice.

Centrophenoxine. Cholinergic precursor that reduces lipofuscin accumulation in neurons.

Molecular structureC12H17Cl2NO3 · 294.17 g/mol

What it is

Cholinergic precursor that reduces lipofuscin accumulation in neurons.

Also called

Meclofenoxate

Food sources

Manufactured pharmaceutical-grade compoundStandardized botanical extract (for plant-derived nootropics)Stack formulations combined with cholinergic or adaptogenic ingredients

Goals

Brain & CognitiveHealthy Aging

How it works

Hydrolyzed to DMAE and pCPA; raises brain acetylcholine and removes lipofuscin deposits.

Pathways

  • Hydrolyzed to DMAE
  • raises brain acetylcholine
  • removes lipofuscin deposits

Effects

  • +Modest cognitive improvement in dementia supports

What the research supports

Modest cognitive improvement in dementialimited

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
250–1000 mg
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodMorning
Best formMost evidence is based on the capsule form.
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Side effects & interactions

Common side effects

  • Insomnia if taken late
  • GI upset

Medication interactions

Prescription medications (general)minor

Always disclose Centrophenoxine use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Omega-3 (EPA/DHA)Membrane fluidity and neuronal signaling support.
  • Alpha-GPC or CDP-cholineProvides choline substrate for acetylcholine synthesis.
  • NAD+ precursor (NMN or NR)Complementary mitochondrial and sirtuin support.

Common forms

  • Capsule
  • Powder for stacking
  • Sublingual tablet
  • Liposomal liquid

Key studies

8 studies cited in total.

PubMed: Centrophenoxine — Modest cognitive improvement in dementia ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Centrophenoxine and "Modest cognitive improvement in dementia". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Centrophenoxine — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Centrophenoxine and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Centrophenoxine — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Centrophenoxine and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

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