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Folate Deficiency

Methylation and NTD prevention.

Ranked by evidence strength across reported benefits.

Herb#1· strong

Ginger

Culinary rhizome with strong antiemetic and anti-inflammatory effects.

Herb#2· strong

Saffron

Culinary spice with antidepressant effects comparable to SSRIs in mild-moderate depression.

Vitamin#3· strong

Vitamin B6 (Pyridoxine)

Cofactor for >100 enzymes including neurotransmitter synthesis.

Vitamin#4· strong

Folate (Vitamin B9)

One-carbon donor essential for DNA synthesis and neural tube development.

Mineral#5· strong

Iron

Oxygen-carrying mineral central to hemoglobin and cellular respiration.

Herb#6· strong

Chasteberry (Vitex)

Dopaminergic herb reducing prolactin and improving PMS/luteal phase symptoms.

Compound#7· strong

Myo-Inositol

Insulin sensitizer used for PCOS and anxiety/OCD support.

Compound#8· strong

Lactobacillus Probiotics

Lactic acid bacteria supporting gut barrier, immunity, and women's urogenital health.

Vitamin#9· strong

Methylfolate (L-5-MTHF)

Bioactive folate that bypasses the MTHFR enzyme — preferred in MTHFR variants and pregnancy.

Herb#10· strong

Tribulus terrestris (Libido)

Steroidal saponin herb claimed for libido and sexual function.

Mineral#11· strong

Ferrous Sulfate

Standard low-cost iron salt — effective but commonly causes GI side effects.

Fatty Acid#12· strong

DHA (Prenatal)

Critical fatty acid for fetal brain and retinal development.

Herb#13· moderate

Tongkat Ali

Malaysian root extract that frees bound testosterone via SHBG reduction.

Herb#14· moderate

Maca

Andean root associated with libido improvement and energy without hormone changes.

Compound#15· moderate

Choline

Essential nutrient for cell membranes, methylation, and acetylcholine synthesis.

Compound#16· moderate

Soy Isoflavones

Phytoestrogens with mild SERM effects on bone, hot flashes, and lipids.

Herb#17· moderate

Tongkat Ali (Eurycoma longifolia)

Malaysian root with moderate human evidence for raising free testosterone and reducing SHBG.

Compound#18· moderate

Myo-Inositol

Insulin-sensitizing sugar alcohol — first-line non-Rx option for PCOS.

Compound#19· moderate

DIM (Diindolylmethane)

Cruciferous-derived compound modulating estrogen metabolism toward 2-OH pathway.

Compound#20· moderate

DIM (Diindolylmethane)

Cruciferous-vegetable metabolite that shifts estrogen metabolism toward 2-OH (protective) pathways.

Herb#21· moderate

Chasteberry (Vitex)

Dopaminergic herb that lowers prolactin and supports luteal-phase progesterone.

Compound#22· moderate

CoQ10 (Fertility)

Mitochondrial antioxidant — improves sperm and oocyte quality.

Vitamin#23· moderate

P-5-P (Pyridoxal-5-Phosphate)

Active coenzyme form of B6 — preferred over pyridoxine HCl for sensitive populations.

Mineral#24· moderate

Calcium

Major bone mineral; also critical for muscle contraction and nerve signaling.

Herb#25· moderate

Black Cohosh

Standardized extract for menopausal vasomotor symptoms.

Herb#26· moderate

Spearmint Tea

Used for hirsutism in PCOS via mild anti-androgen effect.

Herb#27· moderate

Cranberry

Berry with PACs that inhibit E. coli adhesion to urothelium for UTI prevention.

Compound#28· moderate

D-Mannose

Simple sugar that binds E. coli fimbriae, flushing them from the urinary tract.

Herb#29· moderate

Black Cohosh

Phytotherapy for menopausal vasomotor symptoms — non-estrogenic but symptom-active.

Mineral#30· moderate

Iron Bisglycinate

Chelated ferrous iron — best-tolerated form with high absorption and minimal GI distress.

Mineral#31· moderate

Selenomethionine

Organic selenium form — preferred for thyroid (Hashimoto's) and antioxidant support.

Compound#32· moderate

Myo-Inositol

Insulin sensitizer for PCOS and metabolic health.

Herb#33· moderate

Chaste Tree (Vitex)

Vitex agnus-castus for PMS.

Compound#34· moderate

Genistein

Soy isoflavone with bone benefits.

Compound#35· moderate

S-Equol

Daidzein metabolite for menopause.

Herb#36· moderate

Cranberry Extract

Vaccinium macrocarpon for UTI prevention.

Compound#37· moderate

Royal Jelly

Queen bee secretion with 10-HDA.

Fatty Acid#38· moderate

Evening Primrose Oil

GLA omega-6 for skin and PMS.

Fatty Acid#39· limited

Evening Primrose Oil

Omega-6 source rich in GLA, used for atopic dermatitis and cyclical breast pain.

Herb#40· limited

Shatavari

Ayurvedic adaptogen used for female hormone balance and lactation support.

Herb#41· limited

Dong Quai

TCM herb traditionally used for menstrual and menopausal symptoms.

Herb#42· limited

Red Clover

Isoflavone-rich legume traditionally used for menopausal symptoms.

Herb#43· limited

Uva-Ursi

Antibacterial herb for acute uncomplicated UTI; alkaline urine required.

Compound#44· limited

Marine Protein Complex (AminoMar)

Proprietary marine-derived complex (AminoMar) clinically studied for thinning hair in women.