Supplement Scholar
Goal area

Fitness & Performance

Strength, endurance, power, and exercise output.

110 profiles, most-studied first
C5H9NO3S

Glycine + NAC (GlyNAC)

Co-supplementation of glycine and N-acetylcysteine that restores glutathione in older adults and improves multiple hallmarks of aging.

Compound14 studies
C4H11N3O3

Creatine Monohydrate

The most-studied and effective ergogenic aid — replenishes ATP via the phosphocreatine system.

Compound12 studies
Mg

Magnesium

Essential cofactor in 300+ enzymatic reactions, from ATP production to muscle relaxation.

Mineral12 studies
C28H38O6

Ashwagandha

Adaptogenic herb that down-regulates HPA-axis output — lowers cortisol, supports T in stressed men.

Herb11 studies
C59H90O4

Coenzyme Q10

Mitochondrial electron carrier and lipid-soluble antioxidant.

Compound10 studies
C8H10N4O2

Coffee

Caffeine + polyphenol matrix with strong evidence for mortality and T2D reduction.

Compound10 studies
C7H15NO3

L-Carnitine

Shuttles long-chain fatty acids into mitochondria for β-oxidation.

Amino Acid10 studies
C14H19NO9S2

Maca

Andean root associated with libido improvement and energy without hormone changes.

Herb10 studies
C14H20O7

Rhodiola Rosea

Arctic adaptogen — reduces fatigue and improves mental performance under stress.

Herb10 studies
C63H88CoN14O14P

Vitamin B12

Essential cobalamin for methylation, red blood cell formation, and myelin maintenance.

Vitamin10 studies
C8H20NO6P

Alpha-GPC

Bioavailable choline source studied for cognition and acute power output.

Nootropic9 studies
C40H52O4

Astaxanthin

Algal carotenoid that is the strongest membrane antioxidant; UV and eye protection.

Compound9 studies

B-Complex (Drinking Recovery)

Alcohol depletes B1, B6, folate — repletion supports neurological recovery.

Vitamin9 studies
C6H13NO2

BCAAs

Branched-chain amino acids — leucine is the primary mTOR signal for muscle protein synthesis.

Amino Acid9 studies
C24H26N2O13

Beetroot Juice

Dietary nitrate source improving NO production, BP, and endurance performance.

Compound9 studies
C5H11NO2

Betaine Anhydrous (TMG)

Methyl donor — improves power output and lowers homocysteine.

Compound9 studies

Bovine Colostrum

First milk rich in IgG, lactoferrin, and growth factors for immune and gut support.

Compound9 studies
C8H10N4O2

Caffeine

Adenosine antagonist with strong evidence for cognitive and physical performance.

Compound9 studies
C10H19N3O8

Citrulline Malate

NO precursor stacked with malate — improves pump and reduces post-workout soreness.

Amino Acid9 studies
C34H46O18

Eleuthero

Adaptogen used to support stamina, immune function, and stress resilience.

Herb9 studies
C5H10O3

HMB

Leucine metabolite reducing muscle protein breakdown, useful in untrained/elderly populations.

Compound9 studies
C38H49N9O5

Ipamorelin

Selective GH secretagogue researched for muscle and recovery; not FDA approved.

Peptide9 studies
Fe

Iron

Oxygen-carrying mineral central to hemoglobin and cellular respiration.

Mineral9 studies
C6H14N4O2

L-Arginine

Conditionally essential amino acid and direct nitric oxide precursor.

Amino Acid9 studies
C6H13N3O3

L-Citrulline

Arginine precursor with superior bioavailability for NO and pump-driven performance.

Amino Acid9 studies
C6H13N3O3

L-Citrulline (NO Production)

Arginine precursor — most efficient way to raise plasma arginine and NO.

Amino Acid9 studies
C6H13NO2

L-Leucine

Essential BCAA and primary anabolic signaler via mTORC1 activation.

Amino Acid9 studies
C9H11NO3

L-Tyrosine (Dopamine Replenishment)

Catecholamine precursor — replenishes dopamine/norepinephrine pools after stimulant use.

Amino Acid9 studies
C11H15N2O8P

NMN

NAD+ precursor similar to NR; bioavailability route debated.

Compound9 studies
C11H15N2O5+

Nicotinamide Riboside (NR)

NAD+ precursor with bioavailability and longevity research interest.

Compound9 studies
C42H72O14

Panax Ginseng

Adaptogenic ginseng studied for fatigue, cognition, and erectile function.

Herb9 studies
K

Potassium

Major intracellular cation essential for BP control, muscle function, and acid-base balance.

Mineral9 studies
C14H20O7

Rhodiola Rosea

Arctic adaptogen for mental fatigue, burnout, and stress resilience.

Herb9 studies

Shilajit

Himalayan mineral exudate rich in fulvic acid, studied for testosterone and fatigue.

Compound9 studies
C2H7NO3S

Taurine

Conditionally essential amino acid involved in bile salt conjugation, osmoregulation, and cardiac function.

Amino Acid9 studies
C12H17N4OS+

Vitamin B1 (Thiamine)

Cofactor for carbohydrate metabolism and nerve conduction.

Vitamin9 studies
C8H10NO5P-2

Vitamin B6 (Pyridoxine)

Cofactor for >100 enzymes including neurotransmitter synthesis.

Vitamin9 studies
C6H13NO2

Whey Protein

Fast-digesting complete protein rich in leucine for muscle protein synthesis.

Compound9 studies
C15H14O6

(-)-Epicatechin

Cocoa flavanol that suppresses myostatin and improves NO.

Compound8 studies
C15H14O6

(−)-Epicatechin

Cocoa flavanol for follistatin/myostatin.

Compound8 studies
C27H44O7

20-Hydroxyecdysone

Spinach ecdysteroid.

Compound8 studies
C28H34O15

2S-Hesperidin (Cardiose)

Bioactive isomer of hesperidin.

Compound8 studies
C27H42O5

5α-Hydroxy Laxogenin

Plant spirostan for muscle.

Compound8 studies
C15H22N4O2S2

Allithiamine

Garlic-derived fat-soluble thiamine.

Vitamin8 studies
C5H4O5-2

Alpha-Ketoglutarate (AKG)

TCA-cycle intermediate studied for healthspan and frailty.

Compound8 studies
C20H32O2

Arachidonic Acid

Omega-6 for muscle inflammation signaling.

Fatty Acid8 studies
C6H13NO2

BCAA 2:1:1

Leucine:Isoleucine:Valine for muscle.

Amino Acid8 studies
C4H8O3

BHB Salts (Exogenous Ketones)

Beta-hydroxybutyrate salts for rapid ketosis.

Compound8 studies
C27H30O16

Bee Pollen

Pollen collected by bees.

Compound8 studies
C24H26N2O13

Beetroot Nitrate

Inorganic nitrate for NO production.

Compound8 studies
C3H7NO2

Beta-Alanine

Carnosine precursor buffering muscle pH during high-intensity work (60–240 sec).

Amino Acid8 studies
C14H19NO9S2

Black Maca

Lepidium meyenii black variant for energy.

Herb8 studies
C6H13NO2

Brown Rice Protein

Hypoallergenic plant protein.

Compound8 studies
C4H9N3O2

Buffered Creatine (Kre-Alkalyn)

pH-buffered creatine.

Compound8 studies
C165H269N47O46

CJC-1295

GHRH analog with extended half-life.

Peptide8 studies
C6H13NO2

Casein Protein

Slow-digesting milk protein providing sustained amino acid release, popular pre-sleep.

Compound8 studies

Coconut Water

Natural source of potassium and modest sodium for mild rehydration.

Compound8 studies
C10H13N5O3

Cordyceps

Medicinal fungus studied for aerobic capacity and immune modulation.

Mushroom8 studies
C10H13N5O3

Cordyceps Militaris

Cordycepin-rich mushroom for energy and exercise.

Mushroom8 studies
C6H13N3O2

Creatine Ethyl Ester

Ester form of creatine.

Compound8 studies
C4H10ClN3O2

Creatine HCl

Alternative creatine form marketed for higher solubility; efficacy equivalent to monohydrate per gram active creatine.

Amino Acid8 studies

Deer Antler Velvet

IGF-1-containing traditional preparation marketed for recovery.

Compound8 studies
C6H13NO2

EAA Blend (Essential Amino Acids)

Complete essential amino blend.

Amino Acid8 studies
C6H13NO2

EAAs (Essential Amino Acids)

All 9 essential amino acids; superior to BCAAs alone for MPS.

Amino Acid8 studies
C27H44O7

Ecdysterone (Isolated)

Spinach/Rhaponticum-derived steroid with anabolic claims.

Compound8 studies
C6H13NO2

Egg White Protein

Highest PDCAAS plant-free protein.

Compound8 studies

Electrolyte Blend

Sodium-forward electrolyte mix for endurance, low-carb diets, and rehydration.

Mineral8 studies

Electrolyte Mix (Drinking Protocol)

Sodium, potassium, and magnesium to offset alcohol-induced diuresis and hangover dehydration.

Mineral8 studies
C6H13NO2

Essential Amino Acids (EAA)

Full-spectrum EAA blend providing all 9 essentials for MPS.

Amino Acid8 studies
C5H10O3

HMB-Free Acid

Faster-absorbing HMB form.

Compound8 studies

Heme Iron Polypeptide

Heme iron from bovine blood.

Mineral8 studies
C6H13NO2

Hemp Protein

Cannabis sativa seed protein.

Compound8 studies
C23H30N2O4

Kratom (caution)

Atypical opioid herb with stimulant low-dose and sedating high-dose effects; addiction risk.

Herb8 studies
C9H14N4O3

L-Carnosine

Histidine dipeptide — anti-glycation and pH buffering.

Amino Acid8 studies
C9H14N4O3

L-Carnosine

Dipeptide that buffers protons and reduces advanced glycation end-products.

Amino Acid8 studies
C6H13NO2

L-Leucine

Branched-chain amino acid that triggers mTOR.

Amino Acid8 studies
C5H12N2O2

L-Ornithine

Urea-cycle amino acid that lowers fatigue and supports nighttime GH release.

Amino Acid8 studies
C9H11NO3

L-Tyrosine

Catecholamine precursor preserving cognition under stress and sleep deprivation.

Amino Acid8 studies
C9H11NO3

L-Tyrosine (Thyroid Substrate)

Amino acid substrate paired with iodine to form thyroid hormones.

Amino Acid8 studies
C5H11NO2

L-Valine

BCAA for endurance.

Amino Acid8 studies
C6H13NO2

Leucine (Mono)

Pure leucine for mTOR.

Amino Acid8 studies
C27H36N4O5S

MK-677 (Ibutamoren) — Ref

Oral ghrelin mimetic that raises GH/IGF-1 (research reference).

Compound8 studies
C4H8MgN2O4

Magnesium Glycinate

Bisglycinate chelate form of magnesium — gentle, well-absorbed, ideal for sleep.

Mineral8 studies

Methylcobalamin High-Dose

Active B12 form for neuropathy.

Vitamin8 studies
C6H13NO2

Micellar Casein

Slow-digesting milk protein.

Compound8 studies
C15H15NO2S

Modafinil (Rx note)

Wakefulness-promoting Rx — listed for reference; not a supplement.

Compound8 studies
C9H13NO2

P-Synephrine (Bitter Orange)

Bitter orange alkaloid used as ephedrine-replacement fat burner.

Compound8 studies
C14H6N2O8

PQQ

Cofactor stimulating mitochondrial biogenesis (PGC-1α).

Compound8 studies
C14H6N2O8

PQQ (Pyrroloquinoline Quinone)

Redox cofactor for mitochondrial biogenesis.

Compound8 studies
C42H72O14

Panax Ginseng (Sexual Health)

Korean red ginseng with RCT-level evidence for erectile dysfunction.

Herb8 studies
C6H13NO2

Pea Protein Isolate

Plant-based protein.

Compound8 studies
C12H14N2O2

Phenylpiracetam

Racetam + phenethylamine moiety — stimulant-like nootropic with rapid tolerance.

Nootropic8 studies
C12H15N3O2

Phenylpiracetam Hydrazide

Hydrazide analog of phenylpiracetam reported to support memory and locomotion.

Nootropic8 studies
C35H69O8P

Phosphatidic Acid

Phospholipid activator of mTORC1 marketed for hypertrophy.

Compound8 studies
C27H44O7

Rhaponticum Carthamoides

Russian adaptogen with ecdysteroid content for performance.

Herb8 studies
C14H20O7

Rhodiola SHR-5

Standardized Rhodiola for fatigue.

Herb8 studies
C10H18O3

Royal Jelly

Queen bee secretion with 10-HDA.

Compound8 studies
C24H32O7

Schisandra

Adaptogenic berry traditionally used for stamina, liver protection, and stress resilience.

Herb8 studies
Na

Sodium

Primary extracellular cation governing plasma volume and nerve conduction.

Mineral8 studies
CHNaO3

Sodium Bicarbonate

Extracellular buffer used for high-intensity exercise capacity.

Compound8 studies
C32H46N8O6S2

Sulbutiamine

Lipid-soluble thiamine derivative crossing the BBB for fatigue and focus.

Nootropic8 studies
C27H44O7

Suma Root

Brazilian ginseng adaptogen.

Herb8 studies
C27H44O8

Turkesterone

Ajuga turkestanica ecdysteroid.

Compound8 studies
C13H8O4

Urolithin A

Gut-microbial metabolite of ellagitannins — induces mitophagy.

Compound8 studies
C30H48O3

Ursolic Acid

Apple-peel triterpene with anabolic and lipolytic effects in rodents.

Compound8 studies
O5SV

Vanadyl Sulfate

Trace mineral with insulin-mimetic effects studied for T2DM.

Mineral8 studies
C17H20N4O6

Vitamin B2 (Riboflavin)

FAD/FMN precursor central to redox reactions and migraine prophylaxis.

Vitamin8 studies
C9H17NO5

Vitamin B5 (Pantothenic acid)

Component of coenzyme A, central to fatty acid and acetylcholine synthesis.

Vitamin8 studies
C6H13NO2

Whey Protein Isolate

Highly bioavailable protein.

Compound8 studies
C16H18O9

Yerba Mate

South American caffeine-containing tea with saponin and chlorogenic acid content.

Herb8 studies