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Nootropic

Phenylpiracetam

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Phenylpiracetam. Racetam + phenethylamine moiety — stimulant-like nootropic with rapid tolerance.

How it works. Modulates D2 and NMDA; phenethylamine group adds mild adrenergic activity.

What the research supports. 1 graded claims. Strongest: Cognitive and stimulant effects (Russian trials) (limited).

How much to take. Typical dose: 100–200 mg, not daily.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with A high-quality multivitamin, Omega-3 (EPA/DHA).

Common forms. Available as Capsule, Powder for stacking, Sublingual tablet, Liposomal liquid.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Phenylpiracetam. Anecdotes are not medical advice.

Phenylpiracetam. Racetam + phenethylamine moiety — stimulant-like nootropic with rapid tolerance.

Molecular structureC12H14N2O2 · 218.25 g/mol

What it is

Racetam + phenethylamine moiety — stimulant-like nootropic with rapid tolerance.

Food sources

Manufactured pharmaceutical-grade compoundStandardized botanical extract (for plant-derived nootropics)Stack formulations combined with cholinergic or adaptogenic ingredients

Goals

FocusCognitive PerformanceEnergy Production

How it works

Modulates D2 and NMDA; phenethylamine group adds mild adrenergic activity.

Pathways

  • Modulates D2
  • phenethylamine group adds mild adrenergic activity

Effects

  • +Cognitive and stimulant effects (Russian trials) supports

What the research supports

Cognitive and stimulant effects (Russian trials)limited

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
100–200 mg, not daily
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodOptional
Best formMost evidence is based on the capsule form.
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Side effects & interactions

Common side effects

  • Tolerance within days

Medication interactions

Prescription medications (general)minor

Always disclose Phenylpiracetam use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
  • Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.

Common forms

  • Capsule
  • Powder for stacking
  • Sublingual tablet
  • Liposomal liquid

Key studies

8 studies cited in total.

PubMed: Phenylpiracetam — Cognitive and stimulant effects ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Phenylpiracetam and "Cognitive and stimulant effects". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Phenylpiracetam — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Phenylpiracetam and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Phenylpiracetam — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Phenylpiracetam and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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