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Rhodiola SHR-5

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Rhodiola SHR-5. Standardized Rhodiola for fatigue.

How it works. Rosavins/salidroside modulate HPA and 5-HT.

What the research supports. 1 graded claims. Strongest: Reduces fatigue (moderate).

How much to take. Typical dose: 200–400 mg.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with A high-quality multivitamin, Omega-3 (EPA/DHA).

Common forms. Available as Standardized extract capsule, Liquid tincture (alcohol or glycerin), Powdered whole herb, Traditional decoction or tea.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Rhodiola SHR-5. Anecdotes are not medical advice.

Rhodiola SHR-5. Standardized Rhodiola for fatigue.

Key compound: salidrosideC14H20O7 · 300.30 g/mol

What it is

Standardized Rhodiola for fatigue.

Food sources

Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice

Goals

Energy ProductionMood & Anxiety

How it works

Rosavins/salidroside modulate HPA and 5-HT.

Pathways

  • Rosavins/salidroside modulate HPA

Effects

  • ↓fatigue decreases

What the research supports

Reduces fatiguemoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
200–400 mg
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodEither with or without food.
Best formMost evidence is based on the standardized extract capsule form.
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Side effects & interactions

Common side effects

  • Insomnia at high dose

Medication interactions

Prescription medications (general)minor

Always disclose Rhodiola SHR-5 use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
  • Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.

Common forms

  • Standardized extract capsule
  • Liquid tincture (alcohol or glycerin)
  • Powdered whole herb
  • Traditional decoction or tea

Key studies

8 studies cited in total.

PubMed: Rhodiola SHR-5 — Reduces fatigue ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Rhodiola SHR-5 and "Reduces fatigue". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Rhodiola SHR-5 — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Rhodiola SHR-5 and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Rhodiola SHR-5 — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Rhodiola SHR-5 and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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