Alpha-GPC
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Alpha-GPC. Bioavailable choline source studied for cognition and acute power output.
How it works. Provides choline for acetylcholine synthesis and membrane phosphatidylcholine.
What the research supports. 2 graded claims. Strongest: Improves cognition in vascular dementia (moderate).
How much to take. Typical dose: 300–600 mg. Morning or pre-workout.
Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.
Stacking. Pairs well with Caffeine.
Common forms. Available as Alpha-GPC 50%, Alpha-GPC 99%.
Key studies. 9 studies cited. The strongest are listed with links to PubMed.
Community. Experiences from people who have tried Alpha-GPC. Anecdotes are not medical advice.
Alpha-GPC. Bioavailable choline source studied for cognition and acute power output.
What it is
Phospholipid choline precursor that crosses the BBB efficiently.
Also called
Food sources
Goals
How it works
Provides choline for acetylcholine synthesis and membrane phosphatidylcholine.
Pathways
- Acetylcholine synthesis
Effects
- ↑Acetylcholine availability increases
- ↑Power output (acute) increases
What the research supports
Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.
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Side effects & interactions
Common side effects
- Headache (often from too much choline)
Medication interactions
Antagonistic effects.
Check any supplement–medication combination with your pharmacist before starting.
Common forms
- Alpha-GPC 50%
- Alpha-GPC 99%
Key studies
9 studies cited in total.
Opens current human and preclinical literature matching Alpha-GPC and "Improves cognition in vascular dementia". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching Alpha-GPC and "Acutely increases power output". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching Alpha-GPC and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.
Discussion
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