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Vitamin B5 (Pantothenic acid)

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Vitamin B5 (Pantothenic acid). Component of coenzyme A, central to fatty acid and acetylcholine synthesis.

How it works. Forms coenzyme A and acyl-carrier protein, required for fatty acid synthesis and citric acid cycle.

What the research supports. 1 graded claims. Strongest: Pantethine modestly lowers LDL/TG (limited).

How much to take. Typical dose: 5 mg general; 600–1200 mg pantethine for lipids.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Collagen peptides, Vitamin C.

Common forms. Available as Calcium pantothenate, Pantethine.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Vitamin B5 (Pantothenic acid). Anecdotes are not medical advice.

Vitamin B5 (Pantothenic acid). Component of coenzyme A, central to fatty acid and acetylcholine synthesis.

Molecular structureC9H17NO5 · 219.23 g/mol

What it is

Component of coenzyme A, central to fatty acid and acetylcholine synthesis.

Food sources

Almost all foodsLiverEgg yolk

Goals

Skin, Hair & NailsEnergy ProductionGeneral Wellness

How it works

Forms coenzyme A and acyl-carrier protein, required for fatty acid synthesis and citric acid cycle.

Pathways

  • CoA synthesis
  • Fatty acid oxidation

Effects

  • +Coenzyme A pools supports

What the research supports

Pantethine modestly lowers LDL/TGlimited

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
5 mg general; 600–1200 mg pantethine for lipids
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodWith a meal containing fat for fat-soluble compounds; otherwise either.
Best formMost evidence is based on the calcium pantothenate form.
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Side effects & interactions

Medication interactions

Prescription medications (general)minor

Always disclose Vitamin B5 (Pantothenic acid) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Collagen peptidesProvides amino acid substrate for connective tissue synthesis.
  • Vitamin CRequired cofactor for collagen hydroxylation.

Common forms

  • Calcium pantothenate
  • Pantethine

Key studies

8 studies cited in total.

PubMed: Vitamin B5 (Pantothenic acid) — Pantethine modestly lowers LDL/TG ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Vitamin B5 (Pantothenic acid) and "Pantethine modestly lowers LDL/TG". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Vitamin B5 (Pantothenic acid) — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Vitamin B5 (Pantothenic acid) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Vitamin B5 (Pantothenic acid) — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Vitamin B5 (Pantothenic acid) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

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