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Vitamin

Vitamin B6 (Pyridoxine)

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Vitamin B6 (Pyridoxine). Cofactor for >100 enzymes including neurotransmitter synthesis.

How it works. PLP cofactor for transaminases and decarboxylases including DDC (dopamine, serotonin, GABA synthesis).

What the research supports. 2 graded claims. Strongest: Reduces nausea in pregnancy (strong).

How much to take. Typical dose: 25–50 mg P5P.

Side effects and interactions. 1 medication interaction listed. Serious: Sensory neuropathy >200 mg/d chronically.

Stacking. Pairs well with A high-quality multivitamin, Omega-3 (EPA/DHA).

Forms. 1 forms. Pick one to open its profile.

Key studies. 9 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Vitamin B6 (Pyridoxine). Anecdotes are not medical advice.

Vitamin B6 (Pyridoxine). Cofactor for >100 enzymes including neurotransmitter synthesis.

Molecular structureC8H10NO5P-2 · 231.14 g/mol

What it is

Cofactor for >100 enzymes including neurotransmitter synthesis.

Also called

P5PPyridoxal-5-phosphate

Food sources

PoultryFishPotatoesChickpeas

Goals

Mood & AnxietyWomen's HealthEnergy Production

How it works

PLP cofactor for transaminases and decarboxylases including DDC (dopamine, serotonin, GABA synthesis).

Pathways

  • Amino acid metabolism
  • Neurotransmitter synthesis

Effects

  • +Serotonin & GABA synthesis supports
  • ↓Homocysteine decreases

What the research supports

Reduces nausea in pregnancystrong
Reduces PMS symptomsmoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
25–50 mg P5P
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodWith a meal containing fat for fat-soluble compounds; otherwise either.
Best formMost evidence is based on the pyridoxine hcl form.
Upper limit100 mg (long-term)
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Side effects & interactions

Serious

  • Sensory neuropathy >200 mg/d chronically

Medication interactions

Levodopa (without carbidopa)moderate

Peripheral conversion reduces CNS effect.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
  • Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.

Key studies

9 studies cited in total.

PubMed: Vitamin B6 (Pyridoxine) — Reduces PMS symptoms ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Vitamin B6 (Pyridoxine) and "Reduces PMS symptoms". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Vitamin B6 (Pyridoxine) — Reduces nausea in pregnancy ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Vitamin B6 (Pyridoxine) and "Reduces nausea in pregnancy". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Vitamin B6 (Pyridoxine) — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Vitamin B6 (Pyridoxine) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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