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Compound

Ecdysterone (Isolated)

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Ecdysterone (Isolated). Spinach/Rhaponticum-derived steroid with anabolic claims.

How it works. Likely ER-β agonism; some evidence for mTOR activation.

What the research supports. 1 graded claims. Strongest: Increases lean mass with resistance training (limited).

How much to take. Typical dose: 30–200 mg.

Side effects and interactions. 1 medication interaction listed. Serious: WADA banned.

Stacking. Pairs well with Creatine monohydrate, Whey or EAAs.

Common forms. Available as Capsule or softgel, Powder, Sublingual or buccal, Liposomal liquid.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Ecdysterone (Isolated). Anecdotes are not medical advice.

Ecdysterone (Isolated). Spinach/Rhaponticum-derived steroid with anabolic claims.

Molecular structureC27H44O7 · 480.6 g/mol

What it is

Spinach/Rhaponticum-derived steroid with anabolic claims.

Food sources

Endogenously produced or biosynthesized moleculeStandardized pharmaceutical- or food-grade supplementCombined with cofactors that improve absorption or activity

Goals

Muscle GrowthAthletic Performance

How it works

Likely ER-β agonism; some evidence for mTOR activation.

Pathways

  • Likely ER-β agonism
  • some evidence for mTOR activation

Effects

  • ↑lean mass with resistance training increases

What the research supports

Increases lean mass with resistance traininglimited

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
30–200 mg
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodWith a meal containing fat for fat-soluble compounds; otherwise either.
Best formMost evidence is based on the capsule or softgel form.
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Side effects & interactions

Serious

  • WADA banned

Medication interactions

Prescription medications (general)minor

Always disclose Ecdysterone (Isolated) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Creatine monohydrateFoundational support for strength, power, and lean mass.
  • Whey or EAAsProvides amino acid substrate for muscle protein synthesis.

Common forms

  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Key studies

8 studies cited in total.

PubMed: Ecdysterone (Isolated) — Increases lean mass with resistance training ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Ecdysterone (Isolated) and "Increases lean mass with resistance training". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Ecdysterone (Isolated) — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Ecdysterone (Isolated) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Ecdysterone (Isolated) — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Ecdysterone (Isolated) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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