Supplement Scholar
Compound

5α-Hydroxy Laxogenin

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5α-Hydroxy Laxogenin. Plant spirostan for muscle.

How it works. Anabolic ratio enhancement (claims).

What the research supports. 1 graded claims. Strongest: Limited human data (moderate).

How much to take. Typical dose: 100 mg.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Creatine monohydrate, Whey or EAAs.

Common forms. Available as Capsule or softgel, Powder, Sublingual or buccal, Liposomal liquid.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried 5α-Hydroxy Laxogenin. Anecdotes are not medical advice.

5α-Hydroxy Laxogenin. Plant spirostan for muscle.

Molecular structureC27H42O5 · 446.6 g/mol

What it is

Plant spirostan for muscle.

Food sources

Endogenously produced or biosynthesized moleculeStandardized pharmaceutical- or food-grade supplementCombined with cofactors that improve absorption or activity

Goals

Muscle Growth

How it works

Anabolic ratio enhancement (claims).

Pathways

  • Anabolic ratio enhancement (claims)

Effects

  • +Limited human data supports

What the research supports

Limited human datamoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
100 mg
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodWith a meal containing fat for fat-soluble compounds; otherwise either.
Best formMost evidence is based on the capsule or softgel form.
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Side effects & interactions

Common side effects

  • Unknown

Medication interactions

Prescription medications (general)minor

Always disclose 5α-Hydroxy Laxogenin use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Creatine monohydrateFoundational support for strength, power, and lean mass.
  • Whey or EAAsProvides amino acid substrate for muscle protein synthesis.

Common forms

  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Key studies

8 studies cited in total.

PubMed: 5α-Hydroxy Laxogenin — Limited human data ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching 5α-Hydroxy Laxogenin and "Limited human data". Filter by RCT, meta-analysis, or year on the results page.

PubMed: 5α-Hydroxy Laxogenin — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching 5α-Hydroxy Laxogenin and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: 5α-Hydroxy Laxogenin — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching 5α-Hydroxy Laxogenin and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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