Citrulline Malate
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Citrulline Malate. NO precursor stacked with malate — improves pump and reduces post-workout soreness.
How it works. Citrulline → arginine → NO; malate enters TCA cycle.
What the research supports. 2 graded claims. Strongest: Improves reps to failure (moderate).
How much to take. Typical dose: 6–8 g 30–60 min pre-workout.
Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.
Stacking. Pairs well with Creatine monohydrate, Whey or EAAs.
Common forms. Available as Free-form crystalline powder, Capsules or tablets, Pre-mixed recovery or hydration beverages, Time-release formulations.
Key studies. 9 studies cited. The strongest are listed with links to PubMed.
Community. Experiences from people who have tried Citrulline Malate. Anecdotes are not medical advice.
Citrulline Malate. NO precursor stacked with malate — improves pump and reduces post-workout soreness.
What it is
NO precursor stacked with malate — improves pump and reduces post-workout soreness.
Food sources
Goals
How it works
Citrulline → arginine → NO; malate enters TCA cycle.
Pathways
- Citrulline → arginine → NO
- malate enters TCA cycle
Effects
- +reps to failure supports
- ↓DOMS decreases
What the research supports
Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.
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Side effects & interactions
Common side effects
- GI distress at high dose
Medication interactions
Always disclose Citrulline Malate use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
Check any supplement–medication combination with your pharmacist before starting.
Combines with
Pairs well
- Creatine monohydrateFoundational support for strength, power, and lean mass.
- Whey or EAAsProvides amino acid substrate for muscle protein synthesis.
Common forms
- Free-form crystalline powder
- Capsules or tablets
- Pre-mixed recovery or hydration beverages
- Time-release formulations
Key studies
9 studies cited in total.
Opens current human and preclinical literature matching Citrulline Malate and "Improves reps to failure". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching Citrulline Malate and "Reduces DOMS". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching Citrulline Malate and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.
Discussion
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