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Arthritis Support

OA and RA symptomatic support.

Ranked by evidence strength across reported benefits.

Fatty Acid#1· strong

Omega-3 (EPA/DHA)

Marine long-chain omega-3s — the most-studied anti-inflammatory and cardiovascular nutrient.

Herb#2· strong

Ginger

Culinary rhizome with strong antiemetic and anti-inflammatory effects.

Herb#3· strong

Boswellia

Anti-inflammatory resin used for osteoarthritis and IBD.

Compound#4· strong

CBD (Cannabidiol)

Non-intoxicating cannabinoid studied for anxiety, sleep, and seizures.

Compound#5· strong

Capsaicin

Chili pepper compound that mildly increases thermogenesis and reduces appetite.

Fatty Acid#6· strong

Omega-3 (rTG form)

Re-esterified triglyceride EPA/DHA — ~70% better absorption than ethyl ester form.

Herb#7· moderate

Curcumin

Yellow polyphenol from turmeric — anti-inflammatory and joint-supportive when properly bioavailable.

Compound#8· moderate

Collagen Peptides

Hydrolyzed protein supplying glycine, proline, and hydroxyproline for connective tissue.

Compound#9· moderate

Hyaluronic Acid

Glycosaminoglycan supporting skin hydration and joint lubrication.

Compound#10· moderate

Bromelain

Pineapple proteolytic enzyme with anti-inflammatory and fibrinolytic effects.

Compound#11· moderate

MSM

Organic sulfur source studied for joint pain and exercise recovery.

Compound#12· moderate

Quercetin

Flavonoid with antihistamine and senolytic effects; pairs with bromelain or vitamin C.

Compound#13· moderate

MSM (Methylsulfonylmethane)

Bioavailable sulfur donor for joints, skin, and hair-keratin synthesis.

Compound#14· moderate

Marine Collagen Peptides

Hydrolyzed fish collagen — supplies glycine, proline, and bioactive di/tripeptides for skin and hair.

Fatty Acid#15· moderate

Krill Oil

Phospholipid-bound EPA/DHA from Antarctic krill — includes astaxanthin antioxidant.

Compound#16· moderate

Glucosamine

Cartilage building block; sulfate form has evidence for OA pain reduction.

Compound#17· moderate

Chondroitin

Cartilage glycosaminoglycan used with glucosamine for joint support.

Fatty Acid#18· moderate

Krill Oil

Phospholipid-bound omega-3 with astaxanthin; better bioavailability than fish oil per gram.

Compound#19· moderate

Glucosamine

Amino sugar substrate for glycosaminoglycan synthesis in cartilage.

Compound#20· moderate

Chondroitin Sulfate

GAG component of cartilage matrix — combined with glucosamine for OA.

Compound#21· moderate

UC-II (Undenatured Collagen)

Type II collagen taken at low dose for immune-mediated joint tolerance.

Herb#22· moderate

Boswellia Serrata

Frankincense extract with 5-LOX inhibition — robust evidence for OA pain.

Herb#23· moderate

Curcumin Phytosome (Meriva)

Phosphatidylcholine-complexed curcumin — ~29× higher bioavailability than standard extract.

Herb#24· moderate

Curcumin C3 + Piperine

Classic curcumin extract with black pepper extract — boosts bioavailability ~20× via UGT inhibition.

Fatty Acid#25· limited

Evening Primrose Oil

Omega-6 source rich in GLA, used for atopic dermatitis and cyclical breast pain.

Compound#26· limited

Quercetin

Flavonoid with antihistamine, anti-viral, and senolytic activity.

Mineral#27· limited

Silica (Silicon)

Trace element involved in collagen and connective tissue crosslinking.

Compound#28· limited

Serrapeptase

Silkworm-derived proteolytic enzyme used for inflammation and fibrin breakdown.

Peptide#29· limited

BPC-157

Research peptide derived from gastric protein, studied for tendon and gut healing.

Peptide#30· limited

TB-500 (Thymosin Beta-4)

Synthetic thymosin β-4 fragment researched for tissue repair; not approved.