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evidence · mechanism · dose
Supplements/Peptide

TB-500 (Thymosin Beta-4)

Synthetic thymosin β-4 fragment researched for tissue repair; not approved.

Recovery OptimizationJoint & Connective Tissue

Overview

Synthetic thymosin β-4 fragment researched for tissue repair; not approved.

Natural sources
  • Synthetic peptide
Common forms
  • Injectable

Mechanism of action

Promotes actin polymerization, cell migration, and angiogenesis.

Pathways
  • · Actin polymerization
  • · Angiogenesis

Effects on the body

Supports
Tissue repair (animal)

Organ system effects

Evidence-based benefits

Animal repair data; no robust human evidence

Limited evidence

Potential side effects

Common
    Rare
      Serious
      • · Unregulated; WADA-banned

      Drug interactions

      No notable interactions reported.

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid if you are
      • ·Pregnant or breastfeeding (insufficient safety data)
      • ·Children under 18 (unless directed by a clinician)
      Other notes
      • ·Most research peptides are not FDA-approved for human use outside investigational protocols.

      Supplement interactions

      Pairs well with

      None listed.

      Avoid combining with
      • Athletes (banned)
        WADA Prohibited List.

      Dosing & bioavailability

      Typical dose
      Investigational

      Where to buy

      Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

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      Thorne
      Practitioner-grade · NSF tested

      Scientific evidence (8)

      Systematic reviewAnn N Y Acad Sci · 2012

      Thymosin beta-4 in wound healing

      Goldstein AL, et al.

      Review of Tβ4 in tissue repair.

      Key findings

      Promotes angiogenesis and wound healing in preclinical and early-phase trials.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: TB-500 (Thymosin Beta-4) — Animal repair data; no robust human evidence

      Live PubMed search

      Live results for "TB-500 (Thymosin Beta-4) Animal repair data; no robust human evidence" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching TB-500 (Thymosin Beta-4) and "Animal repair data; no robust human evidence". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: TB-500 (Thymosin Beta-4) — randomized controlled trial

      Live PubMed search

      Live results for "TB-500 (Thymosin Beta-4) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching TB-500 (Thymosin Beta-4) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: TB-500 (Thymosin Beta-4) — meta-analysis

      Live PubMed search

      Live results for "TB-500 (Thymosin Beta-4) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching TB-500 (Thymosin Beta-4) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: TB-500 (Thymosin Beta-4) — pharmacokinetics

      Live PubMed search

      Live results for "TB-500 (Thymosin Beta-4) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching TB-500 (Thymosin Beta-4) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: TB-500 (Thymosin Beta-4) — safety adverse events

      Live PubMed search

      Live results for "TB-500 (Thymosin Beta-4) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching TB-500 (Thymosin Beta-4) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: TB-500 (Thymosin Beta-4) — dose response

      Live PubMed search

      Live results for "TB-500 (Thymosin Beta-4) dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching TB-500 (Thymosin Beta-4) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: TB-500 (Thymosin Beta-4) — clinical evidence

      Live Scholar search

      Cross-database citation index for TB-500 (Thymosin Beta-4) as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.