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evidence · mechanism · dose
Supplements/Compound

UC-II (Undenatured Collagen)

Type II collagen taken at low dose for immune-mediated joint tolerance.

Joint PainArthritis SupportCartilage Health

Overview

Type II collagen taken at low dose for immune-mediated joint tolerance.

Natural sources
    Common forms

      Forms & variants of UC-II (Undenatured Collagen)

      Different chemical forms of UC-II (Undenatured Collagen) behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Joint dose
      UC-II (Undenatured Collagen)

      Undenatured type II collagen acting via oral tolerance for OA.

      Mechanism of action

      Oral tolerance via gut-associated lymphoid tissue down-regulates collagen-targeted autoimmunity.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Superior to glucosamine+chondroitin in head-to-head OA trial

        Moderate evidence

        Potential side effects

        Common
          Rare
            Serious

              Drug interactions

              No notable interactions reported.

              Supplement interactions

              Pairs well with

              None listed.

              Avoid combining with

              No specific avoidances listed.

              Dosing & bioavailability

              Typical dose
              40 mg/d on empty stomach
              With food?
              Empty stomach

              Where to buy

              Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

              Compound
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              Global delivery · curated brands
              Compound
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              Thorne
              Practitioner-grade · NSF tested

              Scientific evidence (8)

              RCTNutr J · 2016

              Undenatured type II collagen for knee osteoarthritis

              Lugo JP, et al.

              180-day RCT of UC-II 40 mg/d vs glucosamine+chondroitin.

              Key findings

              Greater improvement in WOMAC score with UC-II.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: UC-II (Undenatured Collagen) — Superior to glucosamine+chondroitin in head-to-head OA trial

              Live PubMed search

              Live results for "UC-II (Undenatured Collagen) Superior to glucosamine+chondroitin in head-to-head OA trial" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching UC-II (Undenatured Collagen) and "Superior to glucosamine+chondroitin in head-to-head OA trial". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: UC-II (Undenatured Collagen) — randomized controlled trial

              Live PubMed search

              Live results for "UC-II (Undenatured Collagen) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching UC-II (Undenatured Collagen) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: UC-II (Undenatured Collagen) — meta-analysis

              Live PubMed search

              Live results for "UC-II (Undenatured Collagen) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching UC-II (Undenatured Collagen) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: UC-II (Undenatured Collagen) — pharmacokinetics

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              Live results for "UC-II (Undenatured Collagen) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching UC-II (Undenatured Collagen) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: UC-II (Undenatured Collagen) — safety adverse events

              Live PubMed search

              Live results for "UC-II (Undenatured Collagen) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching UC-II (Undenatured Collagen) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: UC-II (Undenatured Collagen) — dose response

              Live PubMed search

              Live results for "UC-II (Undenatured Collagen) dose response" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching UC-II (Undenatured Collagen) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewGoogle Scholar · 1970

              Google Scholar: UC-II (Undenatured Collagen) — clinical evidence

              Live Scholar search

              Cross-database citation index for UC-II (Undenatured Collagen) as it relates to "clinical evidence".

              Key findings

              Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

              Open study
              Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.