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evidence · mechanism · dose
Supplements/Compound

UC-II (Undenatured Collagen)

Undenatured type II collagen acting via oral tolerance for OA.

Overview

Undenatured type II collagen acting via oral tolerance for OA.

Natural sources
    Common forms

      Forms & variants of UC-II (Undenatured Collagen)

      Different chemical forms of UC-II (Undenatured Collagen) behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      UC-II (Undenatured Collagen)

      Type II collagen taken at low dose for immune-mediated joint tolerance.

      Mechanism of action

      Oral tolerance in Peyer's patches downregulates joint autoimmunity.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces knee OA symptoms vs glucosamine+chondroitin

        Strong evidence

        Potential side effects

        Common
          Rare
            Serious

              Drug interactions

              No notable interactions reported.

              Supplement interactions

              Pairs well with

              None listed.

              Avoid combining with

              No specific avoidances listed.

              Dosing & bioavailability

              Typical dose
              40 mg/day
              With food?
              Empty stomach (evening)

              Where to buy

              Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

              Compound
              UC-II (Unden…
              Amazon
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              iHerb
              Global delivery · curated brands
              Compound
              UC-II (Unden…
              Thorne
              Practitioner-grade · NSF tested

              Scientific evidence (8)

              RCTNutr J · 2016

              UC-II vs G+C in knee OA

              Lugo JP, et al.

              180-day DB-RCT in 191 knee OA patients.

              Key findings

              UC-II 40 mg superior to glucosamine 1500 + chondroitin 1200 on WOMAC.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: UC-II (Undenatured Collagen) — Reduces knee OA symptoms vs glucosamine+chondroitin

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              Live results for "UC-II (Undenatured Collagen) Reduces knee OA symptoms vs glucosamine+chondroitin" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching UC-II (Undenatured Collagen) and "Reduces knee OA symptoms vs glucosamine+chondroitin". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: UC-II (Undenatured Collagen) — randomized controlled trial

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              Live results for "UC-II (Undenatured Collagen) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching UC-II (Undenatured Collagen) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: UC-II (Undenatured Collagen) — meta-analysis

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              Live results for "UC-II (Undenatured Collagen) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching UC-II (Undenatured Collagen) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: UC-II (Undenatured Collagen) — pharmacokinetics

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              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: UC-II (Undenatured Collagen) — safety adverse events

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              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: UC-II (Undenatured Collagen) — dose response

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              Key findings

              Opens current human and preclinical literature matching UC-II (Undenatured Collagen) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewGoogle Scholar · 1970

              Google Scholar: UC-II (Undenatured Collagen) — clinical evidence

              Live Scholar search

              Cross-database citation index for UC-II (Undenatured Collagen) as it relates to "clinical evidence".

              Key findings

              Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

              Open study
              Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.