Supplement Scholar
Goal area

Weight Management

Fat loss, appetite, metabolism, and glucose control.

31 profiles, most-studied first
C20H18NO4+

Berberine

Plant alkaloid that activates AMPK — metformin-like effects on glucose and lipids.

Compound10 studies
C8H10N4O2

Coffee

Caffeine + polyphenol matrix with strong evidence for mortality and T2D reduction.

Compound10 studies
C27H42O3

Fenugreek

Spice/herb traditionally for libido & glycemic control; modest free-T effects.

Herb10 studies
C7H15NO3

L-Carnitine

Shuttles long-chain fatty acids into mitochondria for β-oxidation.

Amino Acid10 studies
C11H12N2O3

5-HTP

Direct serotonin precursor with mood and sleep applications.

Amino Acid9 studies
C8H14O2S2

Alpha-Lipoic Acid (ALA)

Universal antioxidant that's both water and fat soluble — supports glycemic control and nerve health.

Compound9 studies
C54H92O23

American Ginseng

Cooler adaptogen with stronger evidence for blood sugar and cold-flu prevention.

Herb9 studies
C20H18NO4+

Berberine (Glucose Use)

AMPK activator with metformin-comparable glucose-lowering effects.

Compound9 studies
C18H27NO3

Capsaicin

Chili pepper compound that mildly increases thermogenesis and reduces appetite.

Compound9 studies
Cr

Chromium

Trace mineral marketed for blood sugar control and carbohydrate cravings.

Mineral9 studies
C24H42O21

Glucomannan (Konjac)

Viscous soluble fiber that promotes satiety and lowers LDL.

Compound9 studies
C22H18O11

Green Tea (EGCG)

Polyphenol-rich tea; EGCG modestly boosts metabolism and supports cardiovascular health.

Herb9 studies
C10H12O2

Holy Basil (Tulsi)

Ayurvedic adaptogen with anti-stress, anti-inflammatory, and glycemic effects.

Herb9 studies
C6H12O6

Myo-Inositol

Insulin sensitizer used for PCOS and anxiety/OCD support.

Compound9 studies

Psyllium Husk

Soluble fiber with strong evidence for cholesterol reduction and bowel regularity.

Compound9 studies
C21H26N2O3

Yohimbine

Alpha-2 adrenergic antagonist used for fat loss and ED; significant cardiovascular risks.

Herb9 studies
C21H26N2O3

Yohimbine

Alpha-2 antagonist — improves erection and fat loss in fasted state but cardiovascular caution.

Compound9 studies

Akkermansia muciniphila

Mucin-degrading commensal linked to metabolic health.

Compound8 studies
C8H14O2S2

Alpha-Lipoic Acid

Mitochondrial antioxidant studied for diabetic neuropathy and insulin sensitivity.

Compound8 studies

Bitter Melon

Traditional anti-diabetic; modest glucose-lowering and weight-loss effects.

Herb8 studies
C9H8O

Cinnamon

Common spice with modest glucose-lowering effects (cassia type studied most).

Herb8 studies
C42H58O6

Fucoxanthin

Brown seaweed carotenoid studied for visceral fat reduction.

Compound8 studies
C6H8O8

Garcinia Cambogia (HCA)

Hydroxycitric acid supplement marketed for weight loss; weak clinical evidence.

Herb8 studies
C43H66O14

Gymnema Sylvestre

Herb that blocks sweet taste perception and modestly lowers glucose.

Herb8 studies
C9H15N3O2S

Maitake D-Fraction

Standardized β-glucan from Grifola frondosa for immune support.

Mushroom8 studies
C25H32O13

Olive Leaf Extract

Mediterranean herb with antihypertensive and immune effects.

Herb8 studies
C25H32O13

Olive Leaf Extract

Polyphenol-rich leaf extract for blood pressure and glucose.

Herb8 studies
C44H70O23

Stevia (Rebaudioside A)

Non-caloric sweetener that may improve glycemia and BP.

Compound8 studies
O5SV

Vanadyl Sulfate

Trace mineral with insulin-mimetic effects studied for T2DM.

Mineral8 studies

White Kidney Bean Extract

α-amylase inhibitor that lowers post-meal carbohydrate absorption.

Herb8 studies
C16H18O9

Yerba Mate

South American caffeine-containing tea with saponin and chlorogenic acid content.

Herb8 studies