Supplement Scholar
Compound

Yohimbine

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Yohimbine. Alpha-2 antagonist — improves erection and fat loss in fasted state but cardiovascular caution.

How it works. Blocks alpha-2 adrenergic auto-receptors, releasing norepinephrine; counters anti-erectile sympathetic tone.

What the research supports. 2 graded claims. Strongest: Effective for psychogenic ED (moderate).

How much to take. Typical dose: 0.2 mg/kg fasted (≈10–15 mg).

Side effects and interactions. 2 medication interactions listed. Serious: Hypertensive crisis.

Stacking. Pairs well with A high-quality multivitamin, Omega-3 (EPA/DHA).

Common forms. Available as Capsule or softgel, Powder, Sublingual or buccal, Liposomal liquid.

Key studies. 9 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Yohimbine. Anecdotes are not medical advice.

Yohimbine. Alpha-2 antagonist — improves erection and fat loss in fasted state but cardiovascular caution.

Molecular structureC21H26N2O3 · 354.4 g/mol

What it is

Alpha-2 antagonist — improves erection and fat loss in fasted state but cardiovascular caution.

Food sources

Endogenously produced or biosynthesized moleculeStandardized pharmaceutical- or food-grade supplementCombined with cofactors that improve absorption or activity

Goals

Erectile FunctionFat Loss (alias)Libido & Sexual HealthMen's Health

How it works

Blocks alpha-2 adrenergic auto-receptors, releasing norepinephrine; counters anti-erectile sympathetic tone.

Pathways

  • Alpha-2 antagonism
  • Lipolysis

Effects

  • ↑Norepinephrine release increases
  • +Erectile response supports

What the research supports

Effective for psychogenic EDmoderate
Increases fasted lipolysismoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
0.2 mg/kg fasted (≈10–15 mg)
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodEmpty stomach
Best formMost evidence is based on the capsule or softgel form.
Upper limitAvoid in HTN/anxiety
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Side effects & interactions

Common side effects

  • Anxiety
  • Tachycardia
  • HTN

Serious

  • Hypertensive crisis
  • Panic attacks

Medication interactions

MAOIs/SSRIssevere

Serotonergic and adrenergic risk.

Anti-hypertensivesmoderate

Interferes with control.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
  • Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.

Common forms

  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Key studies

9 studies cited in total.

Yohimbine for erectile dysfunction: a meta-analysis ↗
Meta-analysis · J Urol · 1998

More effective than placebo for erectile dysfunction.

PubMed: Yohimbine — Effective for psychogenic ED ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Yohimbine and "Effective for psychogenic ED". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Yohimbine — Increases fasted lipolysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Yohimbine and "Increases fasted lipolysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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