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Compound

Myo-Inositol

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Myo-Inositol. Insulin sensitizer used for PCOS and anxiety/OCD support.

How it works. Second messenger in insulin signaling; modulates serotonin signaling.

What the research supports. 2 graded claims. Strongest: Restores ovulation in PCOS (strong).

How much to take. Typical dose: 2 g × 2/d (PCOS); 12–18 g for OCD.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with D-chiro-inositol (40:1).

Common forms. Available as Myo-inositol, D-chiro-inositol (40:1 with myo).

Key studies. 9 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Myo-Inositol. Anecdotes are not medical advice.

Myo-Inositol. Insulin sensitizer used for PCOS and anxiety/OCD support.

Molecular structureC6H12O6 · 180.16 g/mol

What it is

Insulin sensitizer used for PCOS and anxiety/OCD support.

Also called

Inositol

Food sources

CitrusBeansWhole grains

Goals

Women's HealthFertilityBlood Sugar ManagementMood & Anxiety

How it works

Second messenger in insulin signaling; modulates serotonin signaling.

Pathways

  • Insulin signaling
  • 5-HT signaling

Effects

  • +Insulin sensitivity supports
  • +Ovulation in PCOS supports

What the research supports

Restores ovulation in PCOSstrong
Reduces panic disorder symptomsmoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
2 g × 2/d (PCOS); 12–18 g for OCD
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodWith a meal containing fat for fat-soluble compounds; otherwise either.
Best formMost evidence is based on the myo-inositol form.
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Side effects & interactions

Common side effects

  • GI upset (high dose)

Medication interactions

Antidiabeticsminor

Additive.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

Common forms

  • Myo-inositol
  • D-chiro-inositol (40:1 with myo)

Key studies

9 studies cited in total.

Myo-inositol for PCOS and metabolic markers ↗
Meta-analysis · Endocr Connect · 2017

Improved ovulation, insulin sensitivity, and androgen levels.

PubMed: Myo-Inositol — Restores ovulation in PCOS ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Myo-Inositol and "Restores ovulation in PCOS". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Myo-Inositol — Reduces panic disorder symptoms ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Myo-Inositol and "Reduces panic disorder symptoms". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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