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Holy Basil (Tulsi)

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Holy Basil (Tulsi). Ayurvedic adaptogen with anti-stress, anti-inflammatory, and glycemic effects.

How it works. Eugenol and ursolic acid modulate cortisol and COX-2.

What the research supports. 2 graded claims. Strongest: Reduces stress symptoms (moderate).

How much to take. Typical dose: 300–600 mg standardized extract.

Side effects and interactions. 2 medication interactions listed. Serious: Discontinue and seek medical advice if symptoms are severe, persistent, or include difficulty breathing.

Stacking. Pairs well with Ashwagandha, L-theanine.

Forms. 1 forms. Pick one to open its profile.

Key studies. 9 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Holy Basil (Tulsi). Anecdotes are not medical advice.

Holy Basil (Tulsi). Ayurvedic adaptogen with anti-stress, anti-inflammatory, and glycemic effects.

Key compound: eugenolC10H12O2 · 164.20 g/mol

What it is

Ayurvedic adaptogen with anti-stress, anti-inflammatory, and glycemic effects.

Also called

Ocimum sanctum

Food sources

Ocimum sanctum leaf

Goals

How it works

Eugenol and ursolic acid modulate cortisol and COX-2.

Pathways

  • HPA modulation
  • Anti-inflammatory

Effects

  • ↓Cortisol & subjective stress decreases
  • ↓Fasting glucose decreases

What the research supports

Reduces stress symptomsmoderate
Improves fasting glucose modestlymoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
300–600 mg standardized extract
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodEither with or without food.
Best formMost evidence is based on the standardized extract form.
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Side effects & interactions

Common side effects

  • Holy Basil (Tulsi) is generally well-tolerated at evidence-based doses
  • Mild GI discomfort (nausea, loose stools, or bloating) possible at higher intakes
  • Headache or transient fatigue reported by a small fraction of users

Serious

  • Discontinue and seek medical advice if symptoms are severe, persistent, or include difficulty breathing

Medication interactions

Antidiabeticsminor

Additive hypoglycemia.

Anticoagulantsminor

Mild platelet effects.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

Key studies

9 studies cited in total.

PubMed: Holy Basil (Tulsi) — Reduces stress symptoms ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Holy Basil (Tulsi) and "Reduces stress symptoms". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Holy Basil (Tulsi) — Improves fasting glucose modestly ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Holy Basil (Tulsi) and "Improves fasting glucose modestly". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Holy Basil (Tulsi) — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Holy Basil (Tulsi) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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