Supplement Scholar
Hormones & Endocrine

Cortisol Management

HPA-axis tone and adaptogenic support.

16 profiles, most-studied first
Mg

Magnesium

Essential cofactor in 300+ enzymatic reactions, from ATP production to muscle relaxation.

Mineral12 studies
C28H38O6

Ashwagandha

Adaptogenic herb that down-regulates HPA-axis output — lowers cortisol, supports T in stressed men.

Herb11 studies
C7H14N2O3

L-Theanine

Calm focus — alpha-wave amino acid from green tea that takes the edge off caffeine.

Amino Acid10 studies
C14H20O7

Rhodiola Rosea

Arctic adaptogen — reduces fatigue and improves mental performance under stress.

Herb10 studies
C34H46O18

Eleuthero

Adaptogen used to support stamina, immune function, and stress resilience.

Herb9 studies
C10H12O2

Holy Basil (Tulsi)

Ayurvedic adaptogen with anti-stress, anti-inflammatory, and glycemic effects.

Herb9 studies
C42H62O16

Licorice Root

Adrenal-supporting herb; chronic high-dose causes pseudo-aldosteronism.

Herb9 studies
C42H72O14

Panax Ginseng

Adaptogenic ginseng studied for fatigue, cognition, and erectile function.

Herb9 studies
C42H82NO10P

Phosphatidylserine (PS)

Phospholipid that supports cognition and may blunt cortisol response to stress.

Compound9 studies
C30H44O7

Reishi

Adaptogenic mushroom used for immune balance, sleep, and stress.

Mushroom9 studies
C28H38O6

Ashwagandha (Cortisol Lowering)

Validated cortisol-lowering adaptogen — ~28% reduction in chronically stressed adults.

Herb8 studies
C28H38O6

Ashwagandha (Thyroid Support)

Supports T4→T3 conversion in subclinical hypothyroid adults.

Herb8 studies
C41H68O13

Bacopa Monnieri

Ayurvedic nootropic with strong evidence for memory consolidation over 8–12 weeks.

Herb8 studies
C9H11NO3

L-Tyrosine

Catecholamine precursor preserving cognition under stress and sleep deprivation.

Amino Acid8 studies
C4H8MgN2O4

Magnesium Glycinate

Bisglycinate chelate form of magnesium — gentle, well-absorbed, ideal for sleep.

Mineral8 studies
C24H32O7

Schisandra

Adaptogenic berry traditionally used for stamina, liver protection, and stress resilience.

Herb8 studies