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Yohimbine

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Yohimbine. Alpha-2 adrenergic antagonist used for fat loss and ED; significant cardiovascular risks.

How it works. Antagonizes pre-synaptic alpha-2 adrenergic receptors, increasing NE release and lipolysis.

What the research supports. 2 graded claims. Strongest: Improves erectile function (moderate).

How much to take. Typical dose: 0.1–0.2 mg/kg yohimbine HCl, fasted; avoid in HTN/anxiety.

Side effects and interactions. 2 medication interactions listed. Serious: Hypertensive crisis.

Stacking. Pairs well with A high-quality multivitamin, Omega-3 (EPA/DHA). Avoid combining with Anxiety / panic disorder, Hypertension / cardiac disease.

Common forms. Available as Yohimbine HCl, Yohimbe bark extract.

Key studies. 9 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Yohimbine. Anecdotes are not medical advice.

Yohimbine. Alpha-2 adrenergic antagonist used for fat loss and ED; significant cardiovascular risks.

Key compound: yohimbineC21H26N2O3 · 354.4 g/mol

What it is

Alpha-2 adrenergic antagonist used for fat loss and ED; significant cardiovascular risks.

Also called

Pausinystalia johimbe

Food sources

Pausinystalia johimbe bark

Goals

Fat LossLibido & Sexual Health

How it works

Antagonizes pre-synaptic alpha-2 adrenergic receptors, increasing NE release and lipolysis.

Pathways

  • α2 antagonism

Effects

  • ↑Lipolysis (esp. stubborn fat) increases
  • +Erectile function supports

What the research supports

Improves erectile functionmoderate
Improves stubborn fat loss when lean & fastedlimited

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
0.1–0.2 mg/kg yohimbine HCl, fasted; avoid in HTN/anxiety
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodEither with or without food.
Best formMost evidence is based on the yohimbine hcl form.
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Side effects & interactions

Common side effects

  • Anxiety
  • Tachycardia
  • Hypertension

Serious

  • Hypertensive crisis
  • Arrhythmia

Medication interactions

MAOIs / TCAssevere

Hypertensive crisis.

Stimulantssevere

Additive CV strain.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
  • Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.

Avoid combining

  • Anxiety / panic disorderProvokes panic.
  • Hypertension / cardiac diseaseRaises BP/HR.

Common forms

  • Yohimbine HCl
  • Yohimbe bark extract

Key studies

9 studies cited in total.

Rhodiola rosea for fatigue: a meta-analysis ↗
Meta-analysis · Phytomedicine · 2011

Significant reduction in fatigue and improved performance.

PubMed: Yohimbine — Improves stubborn fat loss when lean & fasted ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Yohimbine and "Improves stubborn fat loss when lean & fasted". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Yohimbine — Improves erectile function ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Yohimbine and "Improves erectile function". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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