Garcinia Cambogia (HCA)
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Garcinia Cambogia (HCA). Hydroxycitric acid supplement marketed for weight loss; weak clinical evidence.
How it works. Inhibits ATP-citrate lyase, reducing fatty acid synthesis.
What the research supports. 1 graded claims. Strongest: Modest weight loss vs placebo (~1 kg) (limited).
How much to take. Typical dose: 500–1500 mg HCA × 3/d.
Side effects and interactions. 2 medication interactions listed. Serious: Hepatotoxicity (rare, formula-related).
Stacking. Pairs well with A high-quality multivitamin, Omega-3 (EPA/DHA).
Common forms. Available as Standardized HCA 50–60%.
Key studies. 8 studies cited. The strongest are listed with links to PubMed.
Community. Experiences from people who have tried Garcinia Cambogia (HCA). Anecdotes are not medical advice.
Garcinia Cambogia (HCA). Hydroxycitric acid supplement marketed for weight loss; weak clinical evidence.
What it is
Hydroxycitric acid supplement marketed for weight loss; weak clinical evidence.
Food sources
Goals
How it works
Inhibits ATP-citrate lyase, reducing fatty acid synthesis.
Pathways
- ATP-citrate lyase inhibition
Effects
- +Appetite reduction (mild) supports
What the research supports
Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.
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Side effects & interactions
Common side effects
- GI upset
Serious
- Hepatotoxicity (rare, formula-related)
Medication interactions
Additive hepatic stress.
Serotonergic effects.
Check any supplement–medication combination with your pharmacist before starting.
Combines with
Pairs well
- A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
- Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.
Common forms
- Standardized HCA 50–60%
Key studies
8 studies cited in total.
Small short-term weight loss; clinical relevance uncertain.
Opens current human and preclinical literature matching Garcinia Cambogia (HCA) and "Modest weight loss vs placebo". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching Garcinia Cambogia (HCA) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.
Discussion
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