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Gotu Kola

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Gotu Kola. Adaptogen used for cognitive support, anxiety, and wound healing.

How it works. Triterpenes (asiaticoside, madecassoside) support collagen synthesis and BDNF.

What the research supports. 2 graded claims. Strongest: Improves wound healing and scar quality (moderate).

How much to take. Typical dose: 500–1000 mg standardized.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Omega-3 (EPA/DHA), Alpha-GPC or CDP-choline, Collagen peptides.

Forms. 1 forms. Pick one to open its profile.

Key studies. 9 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Gotu Kola. Anecdotes are not medical advice.

Gotu Kola. Adaptogen used for cognitive support, anxiety, and wound healing.

Key compound: asiaticosideC48H78O19 · 959.1 g/mol

What it is

Adaptogen used for cognitive support, anxiety, and wound healing.

Also called

Centella asiatica

Food sources

Centella asiatica

Goals

How it works

Triterpenes (asiaticoside, madecassoside) support collagen synthesis and BDNF.

Pathways

  • BDNF ↑
  • Collagen synthesis

Effects

  • +Wound healing supports
  • ↓Anxiety decreases

What the research supports

Improves wound healing and scar qualitymoderate
Reduces anxietylimited

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
500–1000 mg standardized
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodEither with or without food.
Best formMost evidence is based on the standardized asiaticosides form.
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Side effects & interactions

Common side effects

  • GI upset

Medication interactions

Hepatotoxic drugsminor

Theoretical caution.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Omega-3 (EPA/DHA)Membrane fluidity and neuronal signaling support.
  • Alpha-GPC or CDP-cholineProvides choline substrate for acetylcholine synthesis.
  • Collagen peptidesProvides amino acid substrate for connective tissue synthesis.

Key studies

9 studies cited in total.

PubMed: Gotu Kola — Improves wound healing and scar quality ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Gotu Kola and "Improves wound healing and scar quality". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Gotu Kola — Reduces anxiety ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Gotu Kola and "Reduces anxiety". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Gotu Kola — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Gotu Kola and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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