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Gotu Kola (Extra)

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Gotu Kola (Extra). Standardized triterpenes for venous insufficiency and skin healing.

How it works. Asiaticoside and madecassoside upregulate collagen and capillary integrity.

What the research supports. 1 graded claims. Strongest: Reduces chronic venous insufficiency symptoms (strong).

How much to take. Typical dose: 60–180 mg TECA.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Collagen peptides, Vitamin C.

Common forms. Available as Standardized extract capsule, Liquid tincture (alcohol or glycerin), Powdered whole herb, Traditional decoction or tea.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Gotu Kola (Extra). Anecdotes are not medical advice.

Gotu Kola (Extra). Standardized triterpenes for venous insufficiency and skin healing.

Key compound: asiaticosideC48H78O19 · 959.1 g/mol

What it is

Standardized triterpenes for venous insufficiency and skin healing.

Food sources

Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice

Goals

Skin, Hair & Nails

How it works

Asiaticoside and madecassoside upregulate collagen and capillary integrity.

Pathways

  • Asiaticoside
  • madecassoside upregulate collagen
  • capillary integrity

Effects

  • ↓chronic venous insufficiency symptoms decreases

What the research supports

Reduces chronic venous insufficiency symptomsstrong

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
60–180 mg TECA
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodWith food
Best formMost evidence is based on the standardized extract capsule form.
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Side effects & interactions

Common side effects

  • Skin irritation (topical)

Medication interactions

Prescription medications (general)minor

Always disclose Gotu Kola (Extra) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Collagen peptidesProvides amino acid substrate for connective tissue synthesis.
  • Vitamin CRequired cofactor for collagen hydroxylation.

Common forms

  • Standardized extract capsule
  • Liquid tincture (alcohol or glycerin)
  • Powdered whole herb
  • Traditional decoction or tea

Key studies

8 studies cited in total.

PubMed: Gotu Kola (Extra) — Reduces chronic venous insufficiency symptoms ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Gotu Kola (Extra) and "Reduces chronic venous insufficiency symptoms". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Gotu Kola (Extra) — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Gotu Kola (Extra) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Gotu Kola (Extra) — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Gotu Kola (Extra) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

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