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Rhodiola SHR-5 (Fatigue)

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Rhodiola SHR-5 (Fatigue). Adaptogen for stress-related fatigue and burnout.

How it works. Rosavin/salidroside modulate HPA axis and monoamine reuptake.

What the research supports. 1 graded claims. Strongest: Reduces fatigue scores in burnout (moderate).

How much to take. Typical dose: 400 mg SHR-5.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Omega-3 (EPA/DHA), Alpha-GPC or CDP-choline.

Common forms. Available as Standardized extract capsule, Liquid tincture (alcohol or glycerin), Powdered whole herb, Traditional decoction or tea.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Rhodiola SHR-5 (Fatigue). Anecdotes are not medical advice.

Rhodiola SHR-5 (Fatigue). Adaptogen for stress-related fatigue and burnout.

Key compound: salidrosideC14H20O7 · 300.30 g/mol

What it is

Adaptogen for stress-related fatigue and burnout.

Food sources

Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice

Goals

Energy ProductionBrain & Cognitive

How it works

Rosavin/salidroside modulate HPA axis and monoamine reuptake.

Pathways

  • Rosavin/salidroside modulate HPA axis
  • monoamine reuptake

Effects

  • ↓fatigue scores in burnout decreases

What the research supports

Reduces fatigue scores in burnoutmoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
400 mg SHR-5
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodMorning
Best formMost evidence is based on the standardized extract capsule form.
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Side effects & interactions

Common side effects

  • Insomnia if late

Medication interactions

Prescription medications (general)minor

Always disclose Rhodiola SHR-5 (Fatigue) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Omega-3 (EPA/DHA)Membrane fluidity and neuronal signaling support.
  • Alpha-GPC or CDP-cholineProvides choline substrate for acetylcholine synthesis.

Common forms

  • Standardized extract capsule
  • Liquid tincture (alcohol or glycerin)
  • Powdered whole herb
  • Traditional decoction or tea

Key studies

8 studies cited in total.

PubMed: Rhodiola SHR-5 (Fatigue) — Reduces fatigue scores in burnout ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Rhodiola SHR-5 (Fatigue) and "Reduces fatigue scores in burnout". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Rhodiola SHR-5 (Fatigue) — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Rhodiola SHR-5 (Fatigue) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Rhodiola SHR-5 (Fatigue) — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Rhodiola SHR-5 (Fatigue) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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