Passionflower
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Passionflower. Mild anxiolytic and sleep aid with GABA-A modulation.
How it works. Flavonoids (chrysin, vitexin) modulate GABA-A receptor.
What the research supports. 2 graded claims. Strongest: Reduces preoperative anxiety comparable to oxazepam (moderate).
How much to take. Typical dose: 250–500 mg extract.
Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.
Stacking. Pairs well with Magnesium glycinate, L-theanine.
Forms. 1 forms. Pick one to open its profile.
Key studies. 9 studies cited. The strongest are listed with links to PubMed.
Community. Experiences from people who have tried Passionflower. Anecdotes are not medical advice.
Passionflower. Mild anxiolytic and sleep aid with GABA-A modulation.
What it is
Mild anxiolytic and sleep aid with GABA-A modulation.
Also called
Food sources
Goals
How it works
Flavonoids (chrysin, vitexin) modulate GABA-A receptor.
Pathways
- GABA-A modulation
Effects
- ↓Anxiety decreases
What the research supports
Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.
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Side effects & interactions
Common side effects
- Drowsiness
Medication interactions
Additive sedation.
Check any supplement–medication combination with your pharmacist before starting.
Combines with
Pairs well
- Magnesium glycinateComplementary GABAergic calming and improved sleep architecture.
- L-theanineReduces sleep latency without sedation.
Forms
Key studies
9 studies cited in total.
Opens current human and preclinical literature matching Passionflower and "Reduces preoperative anxiety comparable to oxazepam". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching Passionflower and "Mild sleep improvement". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching Passionflower and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.
Discussion
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