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Herb

Passionflower (Anxiety)

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Passionflower (Anxiety). Passiflora incarnata for mild GAD and pre-surgical anxiety.

How it works. Flavonoid chrysin and apigenin modulate GABA-A benzodiazepine sites.

What the research supports. 2 graded claims. Strongest: Reduces pre-surgical anxiety (moderate).

How much to take. Typical dose: 250–500 mg extract.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Magnesium glycinate, L-theanine.

Common forms. Available as Standardized extract capsule, Liquid tincture (alcohol or glycerin), Powdered whole herb, Traditional decoction or tea.

Key studies. 9 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Passionflower (Anxiety). Anecdotes are not medical advice.

Passionflower (Anxiety). Passiflora incarnata for mild GAD and pre-surgical anxiety.

Key compound: chrysinC15H10O4 · 254.24 g/mol

What it is

Passiflora incarnata for mild GAD and pre-surgical anxiety.

Food sources

Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice

Goals

Mood & AnxietySleep & Recovery

How it works

Flavonoid chrysin and apigenin modulate GABA-A benzodiazepine sites.

Pathways

  • Flavonoid chrysin
  • apigenin modulate GABA-A benzodiazepine sites

Effects

  • ↓pre-surgical anxiety decreases
  • +Comparable to oxazepam in GAD supports

What the research supports

Reduces pre-surgical anxietymoderate
Comparable to oxazepam in GADlimited

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
250–500 mg extract
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodEither
Best formMost evidence is based on the standardized extract capsule form.
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Side effects & interactions

Common side effects

  • Sedation

Medication interactions

Prescription medications (general)minor

Always disclose Passionflower (Anxiety) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

Common forms

  • Standardized extract capsule
  • Liquid tincture (alcohol or glycerin)
  • Powdered whole herb
  • Traditional decoction or tea

Key studies

9 studies cited in total.

PubMed: Passionflower (Anxiety) — Reduces pre-surgical anxiety ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Passionflower (Anxiety) and "Reduces pre-surgical anxiety". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Passionflower (Anxiety) — Comparable to oxazepam in GAD ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Passionflower (Anxiety) and "Comparable to oxazepam in GAD". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Passionflower (Anxiety) — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Passionflower (Anxiety) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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