Folate (Vitamin B9)
Affiliate link: we may earn a commission at no extra cost to you. Disclosures
Folate (Vitamin B9). One-carbon donor essential for DNA synthesis and neural tube development.
How it works. Provides methyl groups for DNA synthesis, homocysteine remethylation, and monoamine synthesis.
What the research supports. 2 graded claims. Strongest: Prevents neural tube defects (preconception) (strong).
How much to take. Typical dose: 400–800 mcg DFE.
Side effects and interactions. 2 medication interactions listed. Serious: Masks B12 deficiency.
Stacking. Pairs well with A high-quality multivitamin, Omega-3 (EPA/DHA).
Forms. 1 forms. Pick one to open its profile.
Key studies. 9 studies cited. The strongest are listed with links to PubMed.
Community. Experiences from people who have tried Folate (Vitamin B9). Anecdotes are not medical advice.
Folate (Vitamin B9). One-carbon donor essential for DNA synthesis and neural tube development.
What it is
One-carbon donor essential for DNA synthesis and neural tube development.
Also called
Food sources
Goals
How it works
Provides methyl groups for DNA synthesis, homocysteine remethylation, and monoamine synthesis.
Pathways
- One-carbon metabolism
- Methylation cycle
Effects
- ↓Homocysteine decreases
- +Erythropoiesis supports
What the research supports
Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.
As an Amazon Associate I earn from qualifying purchases. Look for USP, NSF or Informed Sport seals before you buy.
Side effects & interactions
Serious
- Masks B12 deficiency
Medication interactions
Folic acid mitigates toxicity but reduces efficacy in cancer.
Lower folate.
Check any supplement–medication combination with your pharmacist before starting.
Combines with
Pairs well
- A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
- Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.
Key studies
9 studies cited in total.
Opens current human and preclinical literature matching Folate (Vitamin B9) and "Prevents neural tube defects". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching Folate (Vitamin B9) and "Augments SSRIs in depression". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching Folate (Vitamin B9) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.
Discussion
Loading discussion…