Supplement Scholar
Herb

Fadogia Agrestis

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Fadogia Agrestis. African shrub touted for testosterone (rodent data only).

How it works. Putative gonadotropin-mimetic in rats; mechanism in humans unclear.

What the research supports. 1 graded claims. Strongest: Increases testosterone in rats (limited).

How much to take. Typical dose: 300–600 mg (experimental).

Side effects and interactions. 1 medication interaction listed. Serious: Possible testicular toxicity at high doses.

Stacking. Pairs well with A high-quality multivitamin, Omega-3 (EPA/DHA).

Common forms. Available as Standardized extract capsule, Liquid tincture (alcohol or glycerin), Powdered whole herb, Traditional decoction or tea.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Fadogia Agrestis. Anecdotes are not medical advice.

Fadogia Agrestis. African shrub touted for testosterone (rodent data only).

No single structure

What it is

African shrub touted for testosterone (rodent data only).

Food sources

Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice

Goals

Testosterone SupportLibido & Sexual HealthMen's Health

How it works

Putative gonadotropin-mimetic in rats; mechanism in humans unclear.

Pathways

  • Putative gonadotropin-mimetic in rats
  • mechanism in humans unclear

Effects

  • ↑testosterone in rats increases

What the research supports

Increases testosterone in ratslimited

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
300–600 mg (experimental)
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodEither with or without food.
Best formMost evidence is based on the standardized extract capsule form.
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Side effects & interactions

Serious

  • Possible testicular toxicity at high doses

Medication interactions

Prescription medications (general)minor

Always disclose Fadogia Agrestis use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
  • Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.

Common forms

  • Standardized extract capsule
  • Liquid tincture (alcohol or glycerin)
  • Powdered whole herb
  • Traditional decoction or tea

Key studies

8 studies cited in total.

PubMed: Fadogia Agrestis — Increases testosterone in rats ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Fadogia Agrestis and "Increases testosterone in rats". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Fadogia Agrestis — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Fadogia Agrestis and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Fadogia Agrestis — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Fadogia Agrestis and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

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