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Fadogia Agrestis

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Fadogia Agrestis. African shrub popularized for testosterone; limited human data and toxicology concerns.

How it works. Animal studies suggest steroidogenic effects on Leydig cells; no human trials.

What the research supports. 1 graded claims. Strongest: No human RCTs (anecdotal).

How much to take. Typical dose: 300–600 mg (anecdotal); no validated human dosing.

Side effects and interactions. 1 medication interaction listed. Serious: Possible testicular/hepatic toxicity (rodent at high dose).

Stacking. Pairs well with A high-quality multivitamin, Omega-3 (EPA/DHA). Avoid combining with Pregnancy.

Forms. 1 forms. Pick one to open its profile.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Fadogia Agrestis. Anecdotes are not medical advice.

Fadogia Agrestis. African shrub popularized for testosterone; limited human data and toxicology concerns.

No single structure

What it is

African shrub popularized for testosterone; limited human data and toxicology concerns.

Food sources

Fadogia agrestis stem

Goals

Testosterone SupportMen's Health

How it works

Animal studies suggest steroidogenic effects on Leydig cells; no human trials.

Pathways

  • Leydig cell stimulation (animal)

Effects

  • ↑Testosterone (rodent) increases

What the research supports

No human RCTsanecdotal

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
300–600 mg (anecdotal); no validated human dosing
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodEither with or without food.
Best formMost evidence is based on the standardized extract form.
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Side effects & interactions

Serious

  • Possible testicular/hepatic toxicity (rodent at high dose)

Medication interactions

Prescription medications (general)minor

Always disclose Fadogia Agrestis use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
  • Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.

Avoid combining

  • PregnancyNo safety data.

Key studies

8 studies cited in total.

PubMed: Fadogia Agrestis — No human RCTs ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Fadogia Agrestis and "No human RCTs". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Fadogia Agrestis — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Fadogia Agrestis and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Fadogia Agrestis — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Fadogia Agrestis and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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