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Compound

Betaine (Liver)

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Betaine (Liver). TMG methyl donor used for fatty liver and homocysteinemia.

How it works. Provides methyl groups for homocysteine remethylation and phosphatidylcholine synthesis.

What the research supports. 1 graded claims. Strongest: Improves steatosis in NAFLD (moderate).

How much to take. Typical dose: 10–20 g/day.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Milk thistle (silymarin), NAC, Omega-3.

Common forms. Available as Capsule or softgel, Powder, Sublingual or buccal, Liposomal liquid.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Betaine (Liver). Anecdotes are not medical advice.

Betaine (Liver). TMG methyl donor used for fatty liver and homocysteinemia.

Molecular structureC5H11NO2 · 117.15 g/mol

What it is

TMG methyl donor used for fatty liver and homocysteinemia.

Food sources

Endogenously produced or biosynthesized moleculeStandardized pharmaceutical- or food-grade supplementCombined with cofactors that improve absorption or activity

Goals

Liver HealthCardiovascular Health

How it works

Provides methyl groups for homocysteine remethylation and phosphatidylcholine synthesis.

Pathways

  • Provides methyl groups for homocysteine remethylation
  • phosphatidylcholine synthesis

Effects

  • +steatosis in NAFLD supports

What the research supports

Improves steatosis in NAFLDmoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
10–20 g/day
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodWith meals
Best formMost evidence is based on the capsule or softgel form.
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Side effects & interactions

Common side effects

  • Fishy odor

Medication interactions

Prescription medications (general)minor

Always disclose Betaine (Liver) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Milk thistle (silymarin)Complementary hepatoprotective antioxidant pathways.
  • NACRestores hepatic glutathione.
  • Omega-3Anti-inflammatory cardiovascular synergy.

Common forms

  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Key studies

8 studies cited in total.

PubMed: Betaine (Liver) — Improves steatosis in NAFLD ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Betaine (Liver) and "Improves steatosis in NAFLD". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Betaine (Liver) — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Betaine (Liver) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Betaine (Liver) — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Betaine (Liver) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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